Engineered Axonal Tracts as “Living Electrodes” for Synaptic-Based Modulation of Neural Circuitry

Mijail D. Serruya, James P. Harris, Dayo O. Adewole, Laura A. Struzyna, Justin C. Burrell, Ashley Nemes, Dmitriy Petrov, Reuben H. Kraft, H. Isaac Chen, John A. Wolf, D. Kacy Cullen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Brain–computer interface and neuromodulation strategies relying on penetrating non-organic electrodes/optrodes are limited by an inflammatory foreign body response that ultimately diminishes performance. A novel “biohybrid” strategy is advanced, whereby living neurons, biomaterials, and microelectrode/optical technology are used together to provide a biologically-based vehicle to probe and modulate nervous-system activity. Microtissue engineering techniques are employed to create axon-based “living electrodes”, which are columnar microstructures comprised of neuronal population(s) projecting long axonal tracts within the lumen of a hydrogel designed to chaperone delivery into the brain. Upon microinjection, the axonal segment penetrates to prescribed depth for synaptic integration with local host neurons, with the perikaryal segment remaining externalized below conforming electrical–optical arrays. In this paradigm, only the biological component ultimately remains in the brain, potentially attenuating a chronic foreign-body response. Axon-based living electrodes are constructed using multiple neuronal subtypes, each with differential capacity to stimulate, inhibit, and/or modulate neural circuitry based on specificity uniquely afforded by synaptic integration, yet ultimately computer controlled by optical/electrical components on the brain surface. Current efforts are assessing the efficacy of this biohybrid interface for targeted, synaptic-based neuromodulation, and the specificity, spatial density and long-term fidelity versus conventional microelectronic or optical substrates alone.

Original languageEnglish (US)
Article number1701183
JournalAdvanced Functional Materials
Volume28
Issue number12
DOIs
StatePublished - Mar 21 2018

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foreign bodies
brain
axons
Brain
Modulation
neurons
modulation
Electrodes
Neurons
electrodes
nervous system
lumens
Hydrogel
Microelectrodes
Neurology
Biocompatible Materials
Biomaterials
Hydrogels
microelectronics
Microelectronics

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

Cite this

Serruya, M. D., Harris, J. P., Adewole, D. O., Struzyna, L. A., Burrell, J. C., Nemes, A., ... Cullen, D. K. (2018). Engineered Axonal Tracts as “Living Electrodes” for Synaptic-Based Modulation of Neural Circuitry. Advanced Functional Materials, 28(12), [1701183]. https://doi.org/10.1002/adfm.201701183
Serruya, Mijail D. ; Harris, James P. ; Adewole, Dayo O. ; Struzyna, Laura A. ; Burrell, Justin C. ; Nemes, Ashley ; Petrov, Dmitriy ; Kraft, Reuben H. ; Chen, H. Isaac ; Wolf, John A. ; Cullen, D. Kacy. / Engineered Axonal Tracts as “Living Electrodes” for Synaptic-Based Modulation of Neural Circuitry. In: Advanced Functional Materials. 2018 ; Vol. 28, No. 12.
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Serruya, MD, Harris, JP, Adewole, DO, Struzyna, LA, Burrell, JC, Nemes, A, Petrov, D, Kraft, RH, Chen, HI, Wolf, JA & Cullen, DK 2018, 'Engineered Axonal Tracts as “Living Electrodes” for Synaptic-Based Modulation of Neural Circuitry', Advanced Functional Materials, vol. 28, no. 12, 1701183. https://doi.org/10.1002/adfm.201701183

Engineered Axonal Tracts as “Living Electrodes” for Synaptic-Based Modulation of Neural Circuitry. / Serruya, Mijail D.; Harris, James P.; Adewole, Dayo O.; Struzyna, Laura A.; Burrell, Justin C.; Nemes, Ashley; Petrov, Dmitriy; Kraft, Reuben H.; Chen, H. Isaac; Wolf, John A.; Cullen, D. Kacy.

In: Advanced Functional Materials, Vol. 28, No. 12, 1701183, 21.03.2018.

Research output: Contribution to journalArticle

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AU - Serruya, Mijail D.

AU - Harris, James P.

AU - Adewole, Dayo O.

AU - Struzyna, Laura A.

AU - Burrell, Justin C.

AU - Nemes, Ashley

AU - Petrov, Dmitriy

AU - Kraft, Reuben H.

AU - Chen, H. Isaac

AU - Wolf, John A.

AU - Cullen, D. Kacy

PY - 2018/3/21

Y1 - 2018/3/21

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