@article{35d40d9d0f49452ab0dd1eda613d6889,
title = "Engineering an Osmosensor by Pivotal Histidine Positioning within Disordered Helices",
abstract = "A His-Asp/Glu dyad forms the core of EnvZ histidine kinase (HK) osmosensing wherein osmolytes mediate changes in the backbone and side-chain microenvironment, leading to enhanced histidine autophosphorylation. This His-Asp/Glu dyad is highly conserved across diverse HKs, suggesting a unified model for integrating diverse environmental stimuli to a singular histidine phosphorylation response.",
author = "Madhubrata Ghosh and Wang, {Loo Chien} and Huber, {Roland G.} and Yunfeng Gao and Morgan, {Leslie K.} and Tulsian, {Nikhil Kumar} and Bond, {Peter J.} and Kenney, {Linda J.} and Anand, {Ganesh S.}",
note = "Funding Information: This work was supported by grants from the Singapore Ministry of Education Academic Research Fund Tier 3 to G.S.A. ( MOE2012-T3-1-008 ), the Research Centre of Excellence in Mechanobiology at the National University of Singapore , funded by the Ministry of Education , Singapore, and Veterans Affairs Grant IOBX-000372 and NIH AI-123640 to L.J.K. In addition, we wish to thank both reviewers of the manuscript for their insightful feedback. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2019",
month = feb,
day = "5",
doi = "10.1016/j.str.2018.10.012",
language = "English (US)",
volume = "27",
pages = "302--314.e4",
journal = "Structure with Folding & design",
issn = "0969-2126",
publisher = "Cell Press",
number = "2",
}