Enhanced anti-proliferative activity of the combination of tamoxifen plus HER-2-neu antibody

Lois M. Witters, Rakesh Kumar, Vernon Chinchilli, Allan Lipton

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86 Scopus citations

Abstract

HER-2/neu overexpression has been associated with poor prognosis in human breast cancer. Many of these cancers are also ER-positive. A logical therapeutic approach for patients who are ER-positive and overexpress HER-2/neu may be to block both the ER and the HER-2/neu pathways. In our study, we used both the MTT tetrazolium dye assay and 3H-thymidine incorporation to measure the effects of the anti-estrogen Tamoxifen or the 4D5 anti-HER-2/neu antibody alone or in combination on the growth of BT474 human breast cancer cells which express ER and overexpress HER-2/neu. We found an enhanced inhibitory effect on cell proliferation with the combination of Tamoxifen and the antibody compared to that seen by either agent alone. This simultaneous interruption of both the ER and the HER-2/neu pathways may be relevant in the clinical treatment of patients who are both ER-positive and overexpress HER-2/neu.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalBreast Cancer Research and Treatment
Volume42
Issue number1
DOIs
StatePublished - Feb 11 1997

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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