Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus

Sanae Ishii, Masahiro Yamaguchi, Hiroshi Nagao, Masayoshi Mishina, Kensaku Mori

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Microglia participate in immune responses in the brain. However, little is known about the contact-mediated interaction between microglia and neurons. We report here that the cell-to-cell contacts between microglial processes and dendrites of hippocampal CA1 neurons were dramatically increased in density and area following local injection of kainic acid (KA). A similar KA-induced increase in the degree of intercellular contacts was observed in mice lacking telencephalin (TLCN), a neuronal dendritic adhesion molecule of ICAM family. The results suggest that adhesive contacts independent of TLCN and contact-mediated interactions between microglia and dendrites were promoted by excitotoxic brain injury.

Original languageEnglish (US)
Pages (from-to)75-85
Number of pages11
JournalJournal of Neuroimmunology
Volume186
Issue number1-2
DOIs
StatePublished - May 1 2007

Fingerprint

Pyramidal Cells
Kainic Acid
Microglia
Dendrites
Hippocampus
Neurons
Adhesives
Brain Injuries
Injections
Brain

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Ishii, Sanae ; Yamaguchi, Masahiro ; Nagao, Hiroshi ; Mishina, Masayoshi ; Mori, Kensaku. / Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus. In: Journal of Neuroimmunology. 2007 ; Vol. 186, No. 1-2. pp. 75-85.
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Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus. / Ishii, Sanae; Yamaguchi, Masahiro; Nagao, Hiroshi; Mishina, Masayoshi; Mori, Kensaku.

In: Journal of Neuroimmunology, Vol. 186, No. 1-2, 01.05.2007, p. 75-85.

Research output: Contribution to journalArticle

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