Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus

Sanae Hasegawa, Masahiro Yamaguchi, Hiroshi Nagao, Masayoshi Mishina, Kensaku Mori

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Microglia participate in immune responses in the brain. However, little is known about the contact-mediated interaction between microglia and neurons. We report here that the cell-to-cell contacts between microglial processes and dendrites of hippocampal CA1 neurons were dramatically increased in density and area following local injection of kainic acid (KA). A similar KA-induced increase in the degree of intercellular contacts was observed in mice lacking telencephalin (TLCN), a neuronal dendritic adhesion molecule of ICAM family. The results suggest that adhesive contacts independent of TLCN and contact-mediated interactions between microglia and dendrites were promoted by excitotoxic brain injury.

Original languageEnglish (US)
Pages (from-to)75-85
Number of pages11
JournalJournal of Neuroimmunology
Volume186
Issue number1-2
DOIs
StatePublished - May 2007

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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