Enhanced loading and controlled release of antibiotics using nucleic acids as an antibiotic-binding effector in hydrogels

Xiaolong Zhang, Boonchoy Soontornworajit, Zhaoyang Zhang, Niancao Chen, Yong Wang

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Antibiotic delivery is important to treat bacterial infections, one of the most challenging health problems globally. This study explored the application of nucleic acids as an antibiotic-binding effector for antibiotic loading and release. The data showed that the partition coefficient of tetracycline increased proportionally to the oligonucleotide concentration ranging from 0 to 1 mM. Resultantly, the incorporation of the oligonucleotides led to enhanced tetracycline loading in the hydrogels. In addition to the enhanced drug loading, the oligonucleotides could slow the release of tetracycline from the hydrogels. Experiments were further carried out to examine the capability of oligonucleotide-functionalized hydrogels in the inhibition of bacterial growth. The results showed that the oligonucleotide-functionalized hydrogels had higher antibacterial efficiency. Moreover, after tetracycline release, the oligonucleotide-functionalized hydrogels could be refilled with fresh tetracycline to reproduce the capability of inhibiting bacterial growth. Therefore, nucleic acid oligonucleotides are a promising antibiotic-binding effector for hydrogel functionalization in antibiotic delivery (Figure Presented).

Original languageEnglish (US)
Pages (from-to)2202-2210
Number of pages9
JournalBiomacromolecules
Volume13
Issue number7
DOIs
StatePublished - Jul 9 2012

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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