Enhanced parasympathetic tone shortens atrial refractoriness in man

Eric N. Prystowsky, Gerald V. Naccarelli, Warren M. Jackman, Robert L. Rinkenberger, James J. Heger, Douglas P. Zipes

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The purpose of this study was to determine the effects of enhanced vagal tone on human right atrial refractoriness in 12 patients. A specially built neck collar connected to a vacuum source was placed around the patient's neck and enhanced vagal tone was produced during neck suction using intracollar negative pressures of 50 to 60 mm Hg. Refractory periods were determined with a catheter electrode positioned in the high right atrium near the sinus node. Induced neck suction increased the spontaneous sinus cycle length from 837 ± 96 to 1,136 ± 273 ms (p <0.001) and shortened the atrial effective refractory period from 241 ± 24 to 230 ± 20 ms (p <0.01) and the atrial functional refractory period from 272 ± 32 to 262 ± 29 ms (p <0.01). In 2 of 2 patients, collar-induced decreases in atrial refractoriness and increases in spontaneous cycle length were prevented after atropine (0.03 mg/kg) was given intravenously. It is concluded that enhanced vagal tone mediated through muscarinic receptors shortens atrial refractory periods in man.

Original languageEnglish (US)
Pages (from-to)96-100
Number of pages5
JournalThe American journal of cardiology
Volume51
Issue number1
DOIs
StatePublished - Jan 1 1983

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Neck
Suction
Sinoatrial Node
Muscarinic Receptors
Vacuum
Heart Atria
Atropine
Electrodes
Catheters
Pressure

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Prystowsky, E. N., Naccarelli, G. V., Jackman, W. M., Rinkenberger, R. L., Heger, J. J., & Zipes, D. P. (1983). Enhanced parasympathetic tone shortens atrial refractoriness in man. The American journal of cardiology, 51(1), 96-100. https://doi.org/10.1016/S0002-9149(83)80018-6
Prystowsky, Eric N. ; Naccarelli, Gerald V. ; Jackman, Warren M. ; Rinkenberger, Robert L. ; Heger, James J. ; Zipes, Douglas P. / Enhanced parasympathetic tone shortens atrial refractoriness in man. In: The American journal of cardiology. 1983 ; Vol. 51, No. 1. pp. 96-100.
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Prystowsky, EN, Naccarelli, GV, Jackman, WM, Rinkenberger, RL, Heger, JJ & Zipes, DP 1983, 'Enhanced parasympathetic tone shortens atrial refractoriness in man', The American journal of cardiology, vol. 51, no. 1, pp. 96-100. https://doi.org/10.1016/S0002-9149(83)80018-6

Enhanced parasympathetic tone shortens atrial refractoriness in man. / Prystowsky, Eric N.; Naccarelli, Gerald V.; Jackman, Warren M.; Rinkenberger, Robert L.; Heger, James J.; Zipes, Douglas P.

In: The American journal of cardiology, Vol. 51, No. 1, 01.01.1983, p. 96-100.

Research output: Contribution to journalArticle

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