ENIGMA brain injury: Framework, challenges, and opportunities

Emily L. Dennis; David Baron; Brenda Bartnik-Olson; Karen Caeyenberghs; Carrie Esopenko; Frank G. Hillary; Kimbra Kenney; Inga K. Koerte; Alexander P. Lin; Andrew R. Mayer; Stefania Mondello; Alexander Olsen; Paul M. Thompson; David F. Tate; Elisabeth A. Wilde

doi:10.1002/hbm.25046

ENIGMA brain injury: Framework, challenges, and opportunities

Emily L. Dennis, David Baron, Brenda Bartnik-Olson, Karen Caeyenberghs, Carrie Esopenko, Frank G. Hillary, Kimbra Kenney, Inga K. Koerte, Alexander P. Lin, Andrew R. Mayer, Stefania Mondello, Alexander Olsen, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Traumatic brain injury (TBI) is a major cause of disability worldwide, but the heterogeneous nature of TBI with respect to injury severity and health comorbidities make patient outcome difficult to predict. Injury severity accounts for only some of this variance, and a wide range of preinjury, injury-related, and postinjury factors may influence outcome, such as sex, socioeconomic status, injury mechanism, and social support. Neuroimaging research in this area has generally been limited by insufficient sample sizes. Additionally, development of reliable biomarkers of mild TBI or repeated subconcussive impacts has been slow, likely due, in part, to subtle effects of injury and the aforementioned variability. The ENIGMA Consortium has established a framework for global collaboration that has resulted in the largest-ever neuroimaging studies of multiple psychiatric and neurological disorders. Here we describe the organization, recent progress, and future goals of the Brain Injury working group.

Original language	English (US)
Journal	Human Brain Mapping
DOIs	https://doi.org/10.1002/hbm.25046
State	Accepted/In press - 2020

All Science Journal Classification (ASJC) codes

Anatomy
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Neurology
Clinical Neurology

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Dennis, Emily L. ; Baron, David ; Bartnik-Olson, Brenda ; Caeyenberghs, Karen ; Esopenko, Carrie ; Hillary, Frank G. ; Kenney, Kimbra ; Koerte, Inga K. ; Lin, Alexander P. ; Mayer, Andrew R. ; Mondello, Stefania ; Olsen, Alexander ; Thompson, Paul M. ; Tate, David F. ; Wilde, Elisabeth A. / ENIGMA brain injury : Framework, challenges, and opportunities. In: Human Brain Mapping. 2020.

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title = "ENIGMA brain injury: Framework, challenges, and opportunities",

abstract = "Traumatic brain injury (TBI) is a major cause of disability worldwide, but the heterogeneous nature of TBI with respect to injury severity and health comorbidities make patient outcome difficult to predict. Injury severity accounts for only some of this variance, and a wide range of preinjury, injury-related, and postinjury factors may influence outcome, such as sex, socioeconomic status, injury mechanism, and social support. Neuroimaging research in this area has generally been limited by insufficient sample sizes. Additionally, development of reliable biomarkers of mild TBI or repeated subconcussive impacts has been slow, likely due, in part, to subtle effects of injury and the aforementioned variability. The ENIGMA Consortium has established a framework for global collaboration that has resulted in the largest-ever neuroimaging studies of multiple psychiatric and neurological disorders. Here we describe the organization, recent progress, and future goals of the Brain Injury working group.",

author = "Dennis, {Emily L.} and David Baron and Brenda Bartnik-Olson and Karen Caeyenberghs and Carrie Esopenko and Hillary, {Frank G.} and Kimbra Kenney and Koerte, {Inga K.} and Lin, {Alexander P.} and Mayer, {Andrew R.} and Stefania Mondello and Alexander Olsen and Thompson, {Paul M.} and Tate, {David F.} and Wilde, {Elisabeth A.}",

note = "Funding Information: This study was supported by the National Institutes of Health (K99NS096116 to E. L. D. and U54EB020403 to P. M. T.). The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or U.S. Government. Funding Information: P. M. T. received partial research support from Biogen, Inc. for research unrelated to this manuscript. The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or U.S. Government. Publisher Copyright: {\textcopyright} 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

doi = "10.1002/hbm.25046",

language = "English (US)",

journal = "Human Brain Mapping",

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ENIGMA brain injury : Framework, challenges, and opportunities. / Dennis, Emily L.; Baron, David; Bartnik-Olson, Brenda; Caeyenberghs, Karen; Esopenko, Carrie; Hillary, Frank G.; Kenney, Kimbra; Koerte, Inga K.; Lin, Alexander P.; Mayer, Andrew R.; Mondello, Stefania; Olsen, Alexander; Thompson, Paul M.; Tate, David F.; Wilde, Elisabeth A.

In: Human Brain Mapping, 2020.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - ENIGMA brain injury

T2 - Framework, challenges, and opportunities

AU - Dennis, Emily L.

AU - Baron, David

AU - Bartnik-Olson, Brenda

AU - Caeyenberghs, Karen

AU - Esopenko, Carrie

AU - Hillary, Frank G.

AU - Kenney, Kimbra

AU - Koerte, Inga K.

AU - Lin, Alexander P.

AU - Mayer, Andrew R.

AU - Mondello, Stefania

AU - Olsen, Alexander

AU - Thompson, Paul M.

AU - Tate, David F.

AU - Wilde, Elisabeth A.

N1 - Funding Information: This study was supported by the National Institutes of Health (K99NS096116 to E. L. D. and U54EB020403 to P. M. T.). The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or U.S. Government. Funding Information: P. M. T. received partial research support from Biogen, Inc. for research unrelated to this manuscript. The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or U.S. Government. Publisher Copyright: © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - Traumatic brain injury (TBI) is a major cause of disability worldwide, but the heterogeneous nature of TBI with respect to injury severity and health comorbidities make patient outcome difficult to predict. Injury severity accounts for only some of this variance, and a wide range of preinjury, injury-related, and postinjury factors may influence outcome, such as sex, socioeconomic status, injury mechanism, and social support. Neuroimaging research in this area has generally been limited by insufficient sample sizes. Additionally, development of reliable biomarkers of mild TBI or repeated subconcussive impacts has been slow, likely due, in part, to subtle effects of injury and the aforementioned variability. The ENIGMA Consortium has established a framework for global collaboration that has resulted in the largest-ever neuroimaging studies of multiple psychiatric and neurological disorders. Here we describe the organization, recent progress, and future goals of the Brain Injury working group.

AB - Traumatic brain injury (TBI) is a major cause of disability worldwide, but the heterogeneous nature of TBI with respect to injury severity and health comorbidities make patient outcome difficult to predict. Injury severity accounts for only some of this variance, and a wide range of preinjury, injury-related, and postinjury factors may influence outcome, such as sex, socioeconomic status, injury mechanism, and social support. Neuroimaging research in this area has generally been limited by insufficient sample sizes. Additionally, development of reliable biomarkers of mild TBI or repeated subconcussive impacts has been slow, likely due, in part, to subtle effects of injury and the aforementioned variability. The ENIGMA Consortium has established a framework for global collaboration that has resulted in the largest-ever neuroimaging studies of multiple psychiatric and neurological disorders. Here we describe the organization, recent progress, and future goals of the Brain Injury working group.

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U2 - 10.1002/hbm.25046

DO - 10.1002/hbm.25046

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JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

ER -

ENIGMA brain injury: Framework, challenges, and opportunities

Abstract

All Science Journal Classification (ASJC) codes

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