ENISI multiscale modeling of mucosal immune responses driven by high performance computing

Vida Abedi, Raquel Hontecillas, Stefan Hoops, Nathan Liles, Adria Carbo, Pinyi Lu, Casandra Philipson, Josep Abassaganya-Riera

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Computational modeling tools have increasingly important roles in our understanding of biological processes. Computer simulations guide experimental and clinical efforts in an unprecedented rate. This study presents ENteric Immunity Simulator - multiscale modeling (MSM) platform developed for high performance computing (HPC). ENISI MSMv2 is designed for modeling mucosal immune responses. The system scales to 109 agents in HPC simulations. This is an important step towards building large scale information processing representations of immune responses that integrate multiple modeling technologies and spatiotemporal scales ranging from nanoseconds to years and from molecules to systems. Our HPC-driven ENISI MSM platform combines the study of molecular pathways controlling T cell differentiation and tissue level interactions between cells to characterize novel mechanisms of immunoregulation at the gut mucosa.

Original languageEnglish (US)
Title of host publicationProceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015
Editorslng. Matthieu Schapranow, Jiayu Zhou, Xiaohua Tony Hu, Bin Ma, Sanguthevar Rajasekaran, Satoru Miyano, Illhoi Yoo, Brian Pierce, Amarda Shehu, Vijay K. Gombar, Brian Chen, Vinay Pai, Jun Huan
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages680-684
Number of pages5
ISBN (Electronic)9781467367981
DOIs
StatePublished - Dec 16 2015
EventIEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015 - Washington, United States
Duration: Nov 9 2015Nov 12 2015

Publication series

NameProceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015

Conference

ConferenceIEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015
Country/TerritoryUnited States
CityWashington
Period11/9/1511/12/15

All Science Journal Classification (ASJC) codes

  • Software
  • Artificial Intelligence
  • Health Informatics
  • Biomedical Engineering

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