Enrichment of Extracellular Vesicles Via Lipid Nanoprobe-Functionalized Nanostructured Silica Microdevice

Yuan Wan, Mackenzie Maurer, Hong Zhang He, Yi Qiu Xia, Wen Long Zhang, Si Jie Hao, Nelson S. Yee, Si Yang Zheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Extracellular vesicles (EVs), from clinical plasma samples, have recently been used towards applications of cancer diagnostics and treatment monitoring. However, clinical translation has been limited by technical challenges in EV enrichment. Thus, we have reported on the development of a microdevice platform that utilizes dual capture principles for improved EV isolation and enrichment. By utilizing (1) an EV-specific lipid nanoprobe-grafted silica for isolation via EV tethering and (2) EV size-matched nanostructures for isolation via physical trapping, isolation efficiency is increased by nearly three times. Furthermore, this continuous-flow microdevice eliminates plasma protein contaminants by upwards of ~97%.

Original languageEnglish (US)
Title of host publication2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages273-276
Number of pages4
ISBN (Electronic)9781728120072
DOIs
StatePublished - Jun 2019
Event20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII - Berlin, Germany
Duration: Jun 23 2019Jun 27 2019

Publication series

Name2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII

Conference

Conference20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
CountryGermany
CityBerlin
Period6/23/196/27/19

All Science Journal Classification (ASJC) codes

  • Process Chemistry and Technology
  • Spectroscopy
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Electronic, Optical and Magnetic Materials
  • Control and Optimization
  • Instrumentation

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  • Cite this

    Wan, Y., Maurer, M., He, H. Z., Xia, Y. Q., Zhang, W. L., Hao, S. J., Yee, N. S., & Zheng, S. Y. (2019). Enrichment of Extracellular Vesicles Via Lipid Nanoprobe-Functionalized Nanostructured Silica Microdevice. In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII (pp. 273-276). [8808761] (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2019.8808761