Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

Leslea J. Hlusko, Joshua P. Carlson, George Chaplin, Scott A. Elias, John F. Hoffecker, Michaela Huffman, Nina G. Jablonski, Tesla A. Monson, Dennis H. O’Rourke, Marin A. Pilloud, G. Richard Scott

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Because of the ubiquitous adaptability of our material culture, some human populations have occupied extreme environments that intensified selection on existing genomic variation. By 32,000 years ago, people were living in Arctic Beringia, and during the Last Glacial Maximum (LGM; 28,000–18,000 y ago), they likely persisted in the Beringian refugium. Such high latitudes provide only very low levels of UV radiation, and can thereby lead to dangerously low levels of biosynthesized vitamin D. The physiological effects of vitamin D deficiency range from reduced dietary absorption of calcium to a compromised immune system and modified adipose tissue function. The ectodysplasin A receptor (EDAR) gene has a range of pleiotropic effects, including sweat gland density, incisor shoveling, and mammary gland ductal branching. The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago. The dental pleiotropic effects of this allele suggest an even higher occurrence among indigenous people in the Western Hemisphere before European colonization. We hypothesize that selection on EDAR V370A occurred in the Beringian refugium because it increases mammary ductal branching, and thereby may amplify the transfer of critical nutrients in vitamin D-deficient conditions to infants via mothers’ milk. This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.

Original languageEnglish (US)
Pages (from-to)E4426-E4432
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number19
DOIs
StatePublished - May 8 2018

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Ectodysplasin Receptors
Ice
Human Milk
Vitamin D
Fatty Acids
Mothers
Milk
Alleles
Fatty Acid Desaturases
Dietary Calcium
Sweat Glands
Vitamin D Deficiency
Omega-3 Fatty Acids
Incisor
Human Mammary Glands
Multigene Family
Population
Adipose Tissue
Immune System
Tooth

All Science Journal Classification (ASJC) codes

  • General

Cite this

Hlusko, Leslea J. ; Carlson, Joshua P. ; Chaplin, George ; Elias, Scott A. ; Hoffecker, John F. ; Huffman, Michaela ; Jablonski, Nina G. ; Monson, Tesla A. ; O’Rourke, Dennis H. ; Pilloud, Marin A. ; Richard Scott, G. / Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk. In: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Vol. 115, No. 19. pp. E4426-E4432.
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abstract = "Because of the ubiquitous adaptability of our material culture, some human populations have occupied extreme environments that intensified selection on existing genomic variation. By 32,000 years ago, people were living in Arctic Beringia, and during the Last Glacial Maximum (LGM; 28,000–18,000 y ago), they likely persisted in the Beringian refugium. Such high latitudes provide only very low levels of UV radiation, and can thereby lead to dangerously low levels of biosynthesized vitamin D. The physiological effects of vitamin D deficiency range from reduced dietary absorption of calcium to a compromised immune system and modified adipose tissue function. The ectodysplasin A receptor (EDAR) gene has a range of pleiotropic effects, including sweat gland density, incisor shoveling, and mammary gland ductal branching. The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago. The dental pleiotropic effects of this allele suggest an even higher occurrence among indigenous people in the Western Hemisphere before European colonization. We hypothesize that selection on EDAR V370A occurred in the Beringian refugium because it increases mammary ductal branching, and thereby may amplify the transfer of critical nutrients in vitamin D-deficient conditions to infants via mothers’ milk. This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.",
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Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk. / Hlusko, Leslea J.; Carlson, Joshua P.; Chaplin, George; Elias, Scott A.; Hoffecker, John F.; Huffman, Michaela; Jablonski, Nina G.; Monson, Tesla A.; O’Rourke, Dennis H.; Pilloud, Marin A.; Richard Scott, G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 19, 08.05.2018, p. E4426-E4432.

Research output: Contribution to journalArticle

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T1 - Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

AU - Hlusko, Leslea J.

AU - Carlson, Joshua P.

AU - Chaplin, George

AU - Elias, Scott A.

AU - Hoffecker, John F.

AU - Huffman, Michaela

AU - Jablonski, Nina G.

AU - Monson, Tesla A.

AU - O’Rourke, Dennis H.

AU - Pilloud, Marin A.

AU - Richard Scott, G.

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