Environmental tobacco smoke exposure, urine CC-16 levels, and asthma outcomes among Chinese children

Y. N. Ma, Z. Qian, J. Wang, E. Rodemich, Y. L. Lee, X. F. Lv, Y. Q. Liu, Y. Zhao, M. M. Huang, Y. Liu, J. Sun, Q. C. He, G. H. Dong

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Abstract

Background Previous studies have shown the relationship between club cell secretory protein (Clara) (CC-16) and respiratory diseases. However, few studies have explored the associations between urine CC-16 levels and environmental tobacco smoke (ETS) exposure in children. The objective of this study was to evaluate whether ETS exposure is associated with CC-16 when stratified by asthma status. Methods In our study, CC-16 was measured on 537 children aged 9-15 from northeast China in 2011-2012 using the Human Clara Cell Protein ELISA kits. Doctor-diagnosed asthma was defined as having ever been diagnosed with asthma by a physician. The relationship between ETS exposure and urine CC-16 level was assessed using linear regression. Results When stratified by asthma status, a negative association between ETS exposure and urine CC-16 was observed after adjusting for the effects of the related covariates, with an adjusted β coefficient [P value] = -0.31 [0.006] in the first 2 years of life and with an adjusted β coefficient [P value] = -0.68 [0.004] in the first 2 years of life and current. Conclusions Our study shows long-term exposure to ETS was associated with urinary CC-16 among children without asthma.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume70
Issue number3
DOIs
StatePublished - Mar 1 2015

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Ma, Y. N., Qian, Z., Wang, J., Rodemich, E., Lee, Y. L., Lv, X. F., Liu, Y. Q., Zhao, Y., Huang, M. M., Liu, Y., Sun, J., He, Q. C., & Dong, G. H. (2015). Environmental tobacco smoke exposure, urine CC-16 levels, and asthma outcomes among Chinese children. Allergy: European Journal of Allergy and Clinical Immunology, 70(3), 295-301. https://doi.org/10.1111/all.12559