Epidemie dynamics at the human-animal interface

James O. Lloyd-Smith, Dylan George, Kim M. Pepin, Virginia E. Pitzer, Juliet R.C. Pulliam, Andrew P. Dobson, Peter J. Hudson, Bryan T. Grenfell

Research output: Contribution to journalReview article

295 Scopus citations

Abstract

Few infectious diseases are entirely human-specific: Most human pathogens also circulate in animals or else originated in nonhuman hosts. Influenza, plague, and trypanosomiasis are classic examples of zoonotic infections that transmit from animals to humans. The multihost ecology of zoonoses leads to complex dynamics, and analytical tools, such as mathematical modeling, are vital to the development of effective control policies and research agendas. Much attention has focused on modeling pathogens with simpler life cycles and immediate global urgency, such as influenza and severe acute respiratory syndrome. Meanwhile, vector-transmitted, chronic, and protozoan infections have been neglected, as have crucial processes such as cross-species transmission. Progress in understanding and combating zoonoses requires a new generation of models that addresses a broader set of pathogen life histories and integrates across host species and scientific disciplines.

Original languageEnglish (US)
Pages (from-to)1362-1367
Number of pages6
JournalScience
Volume326
Issue number5958
DOIs
Publication statusPublished - Dec 4 2009

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All Science Journal Classification (ASJC) codes

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Lloyd-Smith, J. O., George, D., Pepin, K. M., Pitzer, V. E., Pulliam, J. R. C., Dobson, A. P., ... Grenfell, B. T. (2009). Epidemie dynamics at the human-animal interface. Science, 326(5958), 1362-1367. https://doi.org/10.1126/science.1177345