Epidemiological study of gastro-oesophageal reflux disease: Reflux in spouse as a risk factor

S. Nasseri-Moghaddam, A. Mofid, M. H. Ghotbi, H. Razjouyan, M. Nouraie, A. R. Ramard, H. Zaer-Rezaie, R. Habibi, K. Rafat-Zand, R. Malekzadeh

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48 Scopus citations


Background: Gastro-oesophageal reflux disease (GERD) is a growing health-care problem with variable distribution. Aim: To assess GERD prevalence and risk factors and their possible correlation with pathophysiology in a population-based study. Methods: Individuals aged 18-65 years were enrolled through random cluster sampling in Tehran. Previously validated self-administered questionnaires were used. Results: Of the 2500 questionnaires, 2057 were analysed (mean age: 34.8 ± 13.0 years, 55.1% female). Frequent GERD was seen in 18.2%. Minor symptoms increased prevalence. Female gender (OR: 1.55, 95% CI: 1.01-2.41), BMI >30 kg/m2 (OR: 1.79, 95% CI: 1.03-3.12), less education (OR: 1.52, 95% CI: 1.02-2.27), smoking (OR: 1.83, 95% CI: 1.12-2.99), NSAID use (OR: 4.23, 95% CI: 1.66-10.74) and GERD in spouse (OR: 1.82, 95% CI: 1.18-2.82) were associated with frequent GERD on multivariable analysis. GERD in first-degree relatives (OR: 1.73, 95% CI: 1.23-2.43) and asthma (OR: 4.09, 95% CI: 1.27-13.15) correlated with infrequent GERD. Minor symptoms correlated with GERD history in first-degree relatives, coffee consumption and NSAID use. Prevalence in the past 3 months was similar to that in the past 12 months (P < 0.05). Conclusions: Gastro-oesophageal reflux disease is common in Tehran. The association of 'infrequent symptoms' with GERD history in first-degree relatives and 'frequent symptoms' with GERD history in spouse may point to the presence of yet unknown precipitating environmental factors inducing GERD in a genetically susceptible host. Minor GERD symptoms seem to have independent contribution to GERD. Assessing GERD in the past 3 months predicts prevalence in the past year.

Original languageEnglish (US)
Pages (from-to)144-153
Number of pages10
JournalAlimentary Pharmacology and Therapeutics
Issue number1
StatePublished - Jul 2008

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)


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