Epigenetic synthetic lethality in ovarian clear cell carcinoma: EZH2 and ARID1A mutations

Benjamin G. Bitler, Katherine M. Aird, Rugang Zhang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The components of the Switch/Sucrose non-fermentable (SWI/SNF) complex are mutated in approximately 20% of human cancers. The A/T-rich interacting domain 1A (ARID1A) subunit has one of the highest mutation rates. Most notably, ARID1A is mutated in over 50% of ovarian clear cell carcinomas (OCCCs). We reported that inhibition of enhancer of zeste homology 2 (EZH2) is synthetically lethal in ARID1A-mutated OCCC.

Original languageEnglish (US)
Article numbere1032476
JournalMolecular and Cellular Oncology
Volume3
Issue number1
DOIs
StatePublished - Jan 2 2016

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Epigenomics
Carcinoma
Mutation
Mutation Rate
Sucrose
Neoplasms
Synthetic Lethal Mutations

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Molecular Medicine

Cite this

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Epigenetic synthetic lethality in ovarian clear cell carcinoma : EZH2 and ARID1A mutations. / Bitler, Benjamin G.; Aird, Katherine M.; Zhang, Rugang.

In: Molecular and Cellular Oncology, Vol. 3, No. 1, e1032476, 02.01.2016.

Research output: Contribution to journalArticle

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