Epistatic control of human obesity as revealed by linkage disequilibrium mapping: A report from the NHLBI-sponsored WISE study

Hongying Li, Rongling Wu, Min Lin, Steve G. Terra, Carl J. Pepine, Susan P. McGorray, B. Delia Johnson, Julie A. Johnson

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Obesity is a major risk factor for type II diabetes, hypertension, cardiovascular disease and certain forms of cancers. Obesity is a complex, multifactorial disorder, influenced by a network of genes, as well as diet, age, ethnicity, gender and exercise. Single nucleotide polymorphisms (SNPs) genotyped in six candidate genes for lipolysis and thermogenesis in human adipose tissue were used to identify and estimate epistatic quantitative trait loci (QTL) predisposing to human obesity based on linkage disequilibrium analysis for 105 black women and 538 white women drawn from the Women's Ischemia Syndrome Evaluation (WISE) study. A few pairs of epistatic QTL were found to affect different aspects of human obesity, including body weight, body mass index, waist and hip circumstances and their ratio, based on association studies of SNPs from different candidate genes. For example, two QTL associated with the β1-adrenergic receptor and Gs protein alpha subunit, respectively, trigger significant additive × additive, additive × dominant, dominant × additive and dominant × dominant epistatic effects on body weight in the black population. It appeared that more obesity QTL interactions occur in black than white populations, supporting the view that obesity genes may originate from Africa. Results from this study provide fundamental information about the genetic architecture of human obesity and the evolutionary mechanisms of population differentiation.

Original languageEnglish (US)
Pages (from-to)463-468
Number of pages6
JournalCurrent Genomics
Volume7
Issue number7
DOIs
StatePublished - Nov 1 2006

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National Heart, Lung, and Blood Institute (U.S.)
Chromosome Mapping
Linkage Disequilibrium
Ischemia
Obesity
Quantitative Trait Loci
Single Nucleotide Polymorphism
Body Weight
Population
Genes
Thermogenesis
Gene Regulatory Networks
Lipolysis
Protein Subunits
Medical Genetics
Adrenergic Receptors
Type 2 Diabetes Mellitus
Adipose Tissue
Hip
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Li, Hongying ; Wu, Rongling ; Lin, Min ; Terra, Steve G. ; Pepine, Carl J. ; McGorray, Susan P. ; Johnson, B. Delia ; Johnson, Julie A. / Epistatic control of human obesity as revealed by linkage disequilibrium mapping : A report from the NHLBI-sponsored WISE study. In: Current Genomics. 2006 ; Vol. 7, No. 7. pp. 463-468.
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Epistatic control of human obesity as revealed by linkage disequilibrium mapping : A report from the NHLBI-sponsored WISE study. / Li, Hongying; Wu, Rongling; Lin, Min; Terra, Steve G.; Pepine, Carl J.; McGorray, Susan P.; Johnson, B. Delia; Johnson, Julie A.

In: Current Genomics, Vol. 7, No. 7, 01.11.2006, p. 463-468.

Research output: Contribution to journalReview article

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