Equal 3-year outcomes for kidney transplantation alone in HCV-positive patients with cirrhosis

Afshin Parsikia, Stalin Campos, Kamran Khanmoradi, John Pang, Manjula Balasubramanian, Radi Zaki, Jorge Ortiz

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Kidney transplantation alone in clinically compensated patients with cirrhosis is not well documented. Current guidelines list cirrhosis as a contraindication for kidney transplantation alone. This is an Institutional Review Board-approved retrospective study. We report our experience with a retrospective comparison between transplants in hepatitis C virus-positive (HCV+ ) patients without cirrhosis and HCV+ patients with cirrhosis. All of the patients were followed for at least a full 3-year period. All of the deaths and graft losses were recorded and analyzed using Kaplan-Meier methodology. One- and three-year cumulative patient survival rates for noncirrhotic patients were 91% and 82%, respectively. For cirrhotic patients, one- and three-year cumulative patient survival rates were 100% and 83%, respectively (P = NS). One- and three-year cumulative graft survival rates censored for death were 94% and 81%, and 95% and 82% for the noncirrhosis and cirrhosis groups, respectively (P = NS). Comparable patient and allograft survival rates were observed when standard kidney allograft recipients were analyzed separately. This study is the longest follow-up document in the literature showing that HCV+ clinically ompensated patients with cirrhosis may undergo kidney transplantation alone as a safe and viable practice.

Original languageEnglish (US)
Pages (from-to)142-154
Number of pages13
JournalInternational Surgery
Volume100
Issue number1
DOIs
StatePublished - Jan 2015

All Science Journal Classification (ASJC) codes

  • Surgery

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