Error-related brain activity in young children

Associations with parental anxiety and child temperamental negative emotionality

Dana C. Torpey, Greg Hajcak, Jiyon Kim, Autumn Kujawa, Margaret W. Dyson, Thomas M. Olino, Daniel N. Klein

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: There is increasing interest in error-related brain activity in anxiety disorders. The error-related negativity (ERN) is a negative deflection in the event-related potential approximately 50 ms after errors compared to correct responses. Recent studies suggest that the ERN may be a biomarker for anxiety, as it is positively associated with anxiety disorders and traits in adults and older youth. However, it is not known if the ERN in young children is related to risk for anxiety disorders. We addressed this by examining the association of six-year olds' ERNs with two established risk factors for anxiety: parental anxiety disorder and child temperamental negative emotionality (NE). Method: The ERN was assessed using a Go/No-Go task in a community sample of 413 six-year olds. In a prior assessment at age 3, child temperament was evaluated using a laboratory observational measure and parental psychopathology was assessed using semi-structured diagnostic interviews. Results: Children of mothers with anxiety disorders and children with greater temperamental NE (particularly fearfulness) exhibited significantly smaller ERNs than their peers. Paternal psychopathology, maternal mood and substance use disorders, and child positive emotionality were not associated with children's ERNs. Conclusion: Both maternal anxiety disorders and child NE (particularly fearfulness) were significantly associated with children's ERNs. However, the direction of these associations was opposite to the relations between ERNs and anxiety in older youth and adults. These results suggest that there may be a difference between risk and disorder status in the relation of error-related brain activity to anxiety between early childhood and late childhood/ early adolescence.

Original languageEnglish (US)
Pages (from-to)854-862
Number of pages9
JournalJournal of Child Psychology and Psychiatry and Allied Disciplines
Volume54
Issue number8
DOIs
StatePublished - Aug 1 2013

Fingerprint

Anxiety
Anxiety Disorders
Brain
Mothers
Psychopathology
Temperament
Evoked Potentials
Substance-Related Disorders
Biomarkers
Interviews

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Torpey, Dana C. ; Hajcak, Greg ; Kim, Jiyon ; Kujawa, Autumn ; Dyson, Margaret W. ; Olino, Thomas M. ; Klein, Daniel N. / Error-related brain activity in young children : Associations with parental anxiety and child temperamental negative emotionality. In: Journal of Child Psychology and Psychiatry and Allied Disciplines. 2013 ; Vol. 54, No. 8. pp. 854-862.
@article{5f576c0e5a6e4c19b75c4db6b1d830c4,
title = "Error-related brain activity in young children: Associations with parental anxiety and child temperamental negative emotionality",
abstract = "Background: There is increasing interest in error-related brain activity in anxiety disorders. The error-related negativity (ERN) is a negative deflection in the event-related potential approximately 50 ms after errors compared to correct responses. Recent studies suggest that the ERN may be a biomarker for anxiety, as it is positively associated with anxiety disorders and traits in adults and older youth. However, it is not known if the ERN in young children is related to risk for anxiety disorders. We addressed this by examining the association of six-year olds' ERNs with two established risk factors for anxiety: parental anxiety disorder and child temperamental negative emotionality (NE). Method: The ERN was assessed using a Go/No-Go task in a community sample of 413 six-year olds. In a prior assessment at age 3, child temperament was evaluated using a laboratory observational measure and parental psychopathology was assessed using semi-structured diagnostic interviews. Results: Children of mothers with anxiety disorders and children with greater temperamental NE (particularly fearfulness) exhibited significantly smaller ERNs than their peers. Paternal psychopathology, maternal mood and substance use disorders, and child positive emotionality were not associated with children's ERNs. Conclusion: Both maternal anxiety disorders and child NE (particularly fearfulness) were significantly associated with children's ERNs. However, the direction of these associations was opposite to the relations between ERNs and anxiety in older youth and adults. These results suggest that there may be a difference between risk and disorder status in the relation of error-related brain activity to anxiety between early childhood and late childhood/ early adolescence.",
author = "Torpey, {Dana C.} and Greg Hajcak and Jiyon Kim and Autumn Kujawa and Dyson, {Margaret W.} and Olino, {Thomas M.} and Klein, {Daniel N.}",
year = "2013",
month = "8",
day = "1",
doi = "10.1111/jcpp.12041",
language = "English (US)",
volume = "54",
pages = "854--862",
journal = "Journal of Child Psychology and Psychiatry and Allied Disciplines",
issn = "0021-9630",
publisher = "Wiley-Blackwell",
number = "8",

}

Error-related brain activity in young children : Associations with parental anxiety and child temperamental negative emotionality. / Torpey, Dana C.; Hajcak, Greg; Kim, Jiyon; Kujawa, Autumn; Dyson, Margaret W.; Olino, Thomas M.; Klein, Daniel N.

In: Journal of Child Psychology and Psychiatry and Allied Disciplines, Vol. 54, No. 8, 01.08.2013, p. 854-862.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Error-related brain activity in young children

T2 - Associations with parental anxiety and child temperamental negative emotionality

AU - Torpey, Dana C.

AU - Hajcak, Greg

AU - Kim, Jiyon

AU - Kujawa, Autumn

AU - Dyson, Margaret W.

AU - Olino, Thomas M.

AU - Klein, Daniel N.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Background: There is increasing interest in error-related brain activity in anxiety disorders. The error-related negativity (ERN) is a negative deflection in the event-related potential approximately 50 ms after errors compared to correct responses. Recent studies suggest that the ERN may be a biomarker for anxiety, as it is positively associated with anxiety disorders and traits in adults and older youth. However, it is not known if the ERN in young children is related to risk for anxiety disorders. We addressed this by examining the association of six-year olds' ERNs with two established risk factors for anxiety: parental anxiety disorder and child temperamental negative emotionality (NE). Method: The ERN was assessed using a Go/No-Go task in a community sample of 413 six-year olds. In a prior assessment at age 3, child temperament was evaluated using a laboratory observational measure and parental psychopathology was assessed using semi-structured diagnostic interviews. Results: Children of mothers with anxiety disorders and children with greater temperamental NE (particularly fearfulness) exhibited significantly smaller ERNs than their peers. Paternal psychopathology, maternal mood and substance use disorders, and child positive emotionality were not associated with children's ERNs. Conclusion: Both maternal anxiety disorders and child NE (particularly fearfulness) were significantly associated with children's ERNs. However, the direction of these associations was opposite to the relations between ERNs and anxiety in older youth and adults. These results suggest that there may be a difference between risk and disorder status in the relation of error-related brain activity to anxiety between early childhood and late childhood/ early adolescence.

AB - Background: There is increasing interest in error-related brain activity in anxiety disorders. The error-related negativity (ERN) is a negative deflection in the event-related potential approximately 50 ms after errors compared to correct responses. Recent studies suggest that the ERN may be a biomarker for anxiety, as it is positively associated with anxiety disorders and traits in adults and older youth. However, it is not known if the ERN in young children is related to risk for anxiety disorders. We addressed this by examining the association of six-year olds' ERNs with two established risk factors for anxiety: parental anxiety disorder and child temperamental negative emotionality (NE). Method: The ERN was assessed using a Go/No-Go task in a community sample of 413 six-year olds. In a prior assessment at age 3, child temperament was evaluated using a laboratory observational measure and parental psychopathology was assessed using semi-structured diagnostic interviews. Results: Children of mothers with anxiety disorders and children with greater temperamental NE (particularly fearfulness) exhibited significantly smaller ERNs than their peers. Paternal psychopathology, maternal mood and substance use disorders, and child positive emotionality were not associated with children's ERNs. Conclusion: Both maternal anxiety disorders and child NE (particularly fearfulness) were significantly associated with children's ERNs. However, the direction of these associations was opposite to the relations between ERNs and anxiety in older youth and adults. These results suggest that there may be a difference between risk and disorder status in the relation of error-related brain activity to anxiety between early childhood and late childhood/ early adolescence.

UR - http://www.scopus.com/inward/record.url?scp=84880570510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880570510&partnerID=8YFLogxK

U2 - 10.1111/jcpp.12041

DO - 10.1111/jcpp.12041

M3 - Article

VL - 54

SP - 854

EP - 862

JO - Journal of Child Psychology and Psychiatry and Allied Disciplines

JF - Journal of Child Psychology and Psychiatry and Allied Disciplines

SN - 0021-9630

IS - 8

ER -