Abstract
Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a histopathologic study of this node was undertaken. The immature cells were identified as erythroblasts and pronormoblasts by histochemical staining (periodic acid-Schiff reagent and chloroacetate esterase), immunohistochemical reaction (directed against hemoglobin), and electron microscopy. The diagnosis of erythroleukemic lymph node infiltrate may be missed in the absence of a high index of suspicion. It is concluded that the detection of hemoglobin within malignant cells is most helpful in establishing the diagnosis.
Original language | English (US) |
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Pages (from-to) | 1090-1093 |
Number of pages | 4 |
Journal | Human Pathology |
Volume | 15 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1984 |
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine