Erythroleukemic infiltration of a lymph node: Use of hemoglobin immunohistochemical techniques in diagnosis

John Keifer, Richard Zaino, James O. Ballard

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a histopathologic study of this node was undertaken. The immature cells were identified as erythroblasts and pronormoblasts by histochemical staining (periodic acid-Schiff reagent and chloroacetate esterase), immunohistochemical reaction (directed against hemoglobin), and electron microscopy. The diagnosis of erythroleukemic lymph node infiltrate may be missed in the absence of a high index of suspicion. It is concluded that the detection of hemoglobin within malignant cells is most helpful in establishing the diagnosis.

Original languageEnglish (US)
Pages (from-to)1090-1093
Number of pages4
JournalHuman Pathology
Volume15
Issue number11
DOIs
StatePublished - Nov 1984

Fingerprint

Erythroblasts
Hemoglobins
Lymph Nodes
Leukemia, Erythroblastic, Acute
Periodic Acid
Electron Microscopy
Cell Proliferation
Staining and Labeling
Biopsy

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

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title = "Erythroleukemic infiltration of a lymph node: Use of hemoglobin immunohistochemical techniques in diagnosis",
abstract = "Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a histopathologic study of this node was undertaken. The immature cells were identified as erythroblasts and pronormoblasts by histochemical staining (periodic acid-Schiff reagent and chloroacetate esterase), immunohistochemical reaction (directed against hemoglobin), and electron microscopy. The diagnosis of erythroleukemic lymph node infiltrate may be missed in the absence of a high index of suspicion. It is concluded that the detection of hemoglobin within malignant cells is most helpful in establishing the diagnosis.",
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Erythroleukemic infiltration of a lymph node : Use of hemoglobin immunohistochemical techniques in diagnosis. / Keifer, John; Zaino, Richard; Ballard, James O.

In: Human Pathology, Vol. 15, No. 11, 11.1984, p. 1090-1093.

Research output: Contribution to journalArticle

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AU - Zaino, Richard

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