Abstract
Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a histopathologic study of this node was undertaken. The immature cells were identified as erythroblasts and pronormoblasts by histochemical staining (periodic acid-Schiff reagent and chloroacetate esterase), immunohistochemical reaction (directed against hemoglobin), and electron microscopy. The diagnosis of erythroleukemic lymph node infiltrate may be missed in the absence of a high index of suspicion. It is concluded that the detection of hemoglobin within malignant cells is most helpful in establishing the diagnosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1090-1093 |
| Number of pages | 4 |
| Journal | Human Pathology |
| Volume | 15 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1984 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
Cite this
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Erythroleukemic infiltration of a lymph node : Use of hemoglobin immunohistochemical techniques in diagnosis. / Keifer, John; Zaino, Richard; Ballard, James O.
In: Human Pathology, Vol. 15, No. 11, 11.1984, p. 1090-1093.Research output: Contribution to journal › Article
TY - JOUR
T1 - Erythroleukemic infiltration of a lymph node
T2 - Use of hemoglobin immunohistochemical techniques in diagnosis
AU - Keifer, John
AU - Zaino, Richard
AU - Ballard, James O.
PY - 1984/11
Y1 - 1984/11
N2 - Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a histopathologic study of this node was undertaken. The immature cells were identified as erythroblasts and pronormoblasts by histochemical staining (periodic acid-Schiff reagent and chloroacetate esterase), immunohistochemical reaction (directed against hemoglobin), and electron microscopy. The diagnosis of erythroleukemic lymph node infiltrate may be missed in the absence of a high index of suspicion. It is concluded that the detection of hemoglobin within malignant cells is most helpful in establishing the diagnosis.
AB - Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a histopathologic study of this node was undertaken. The immature cells were identified as erythroblasts and pronormoblasts by histochemical staining (periodic acid-Schiff reagent and chloroacetate esterase), immunohistochemical reaction (directed against hemoglobin), and electron microscopy. The diagnosis of erythroleukemic lymph node infiltrate may be missed in the absence of a high index of suspicion. It is concluded that the detection of hemoglobin within malignant cells is most helpful in establishing the diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=0021671563&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021671563&partnerID=8YFLogxK
U2 - 10.1016/S0046-8177(84)80254-3
DO - 10.1016/S0046-8177(84)80254-3
M3 - Article
C2 - 6386660
AN - SCOPUS:0021671563
VL - 15
SP - 1090
EP - 1093
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 11
ER -