Erythrosine (red no. 3) and its nonspecific biochemical actions: What relation to behavioral changes?

Richard B. Mailman, Robert M. Ferris, Flora L.M. Tang, Richard A. Vogel, Clinton D. Kilts, Morris A. Lipton, Dorothy A. Smith, Robert A. Mueller, George R. Breese

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control or 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.

Original languageEnglish (US)
Pages (from-to)535-537
Number of pages3
JournalScience
Volume207
Issue number4430
DOIs
StatePublished - Jan 1 1980

All Science Journal Classification (ASJC) codes

  • General

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