Erythrosine (red no. 3) and its nonspecific biochemical actions

What relation to behavioral changes?

Richard Mailman, Robert M. Ferris, Flora L.M. Tang, Richard A. Vogel, Clinton D. Kilts, Morris A. Lipton, Dorothy A. Smith, Robert A. Mueller, George R. Breese

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control or 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.

Original languageEnglish (US)
Pages (from-to)535-537
Number of pages3
JournalScience
Volume207
Issue number4430
DOIs
StatePublished - Jan 1 1980

Fingerprint

Erythrosine
Dopamine
Aptitude
Punishment
Oxidopamine
Brain
Locomotion
Artifacts
Membranes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Mailman, R., Ferris, R. M., Tang, F. L. M., Vogel, R. A., Kilts, C. D., Lipton, M. A., ... Breese, G. R. (1980). Erythrosine (red no. 3) and its nonspecific biochemical actions: What relation to behavioral changes? Science, 207(4430), 535-537. https://doi.org/10.1126/science.7352264
Mailman, Richard ; Ferris, Robert M. ; Tang, Flora L.M. ; Vogel, Richard A. ; Kilts, Clinton D. ; Lipton, Morris A. ; Smith, Dorothy A. ; Mueller, Robert A. ; Breese, George R. / Erythrosine (red no. 3) and its nonspecific biochemical actions : What relation to behavioral changes?. In: Science. 1980 ; Vol. 207, No. 4430. pp. 535-537.
@article{e1232b60f10f4aa9a139cd97b32a28ce,
title = "Erythrosine (red no. 3) and its nonspecific biochemical actions: What relation to behavioral changes?",
abstract = "Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control or 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a {"}conflict{"} paradigm.",
author = "Richard Mailman and Ferris, {Robert M.} and Tang, {Flora L.M.} and Vogel, {Richard A.} and Kilts, {Clinton D.} and Lipton, {Morris A.} and Smith, {Dorothy A.} and Mueller, {Robert A.} and Breese, {George R.}",
year = "1980",
month = "1",
day = "1",
doi = "10.1126/science.7352264",
language = "English (US)",
volume = "207",
pages = "535--537",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4430",

}

Mailman, R, Ferris, RM, Tang, FLM, Vogel, RA, Kilts, CD, Lipton, MA, Smith, DA, Mueller, RA & Breese, GR 1980, 'Erythrosine (red no. 3) and its nonspecific biochemical actions: What relation to behavioral changes?', Science, vol. 207, no. 4430, pp. 535-537. https://doi.org/10.1126/science.7352264

Erythrosine (red no. 3) and its nonspecific biochemical actions : What relation to behavioral changes? / Mailman, Richard; Ferris, Robert M.; Tang, Flora L.M.; Vogel, Richard A.; Kilts, Clinton D.; Lipton, Morris A.; Smith, Dorothy A.; Mueller, Robert A.; Breese, George R.

In: Science, Vol. 207, No. 4430, 01.01.1980, p. 535-537.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Erythrosine (red no. 3) and its nonspecific biochemical actions

T2 - What relation to behavioral changes?

AU - Mailman, Richard

AU - Ferris, Robert M.

AU - Tang, Flora L.M.

AU - Vogel, Richard A.

AU - Kilts, Clinton D.

AU - Lipton, Morris A.

AU - Smith, Dorothy A.

AU - Mueller, Robert A.

AU - Breese, George R.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control or 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.

AB - Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control or 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.

UR - http://www.scopus.com/inward/record.url?scp=0018890575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018890575&partnerID=8YFLogxK

U2 - 10.1126/science.7352264

DO - 10.1126/science.7352264

M3 - Article

VL - 207

SP - 535

EP - 537

JO - Science

JF - Science

SN - 0036-8075

IS - 4430

ER -