Escherichia coli sequence type ST131 as an emerging fluoroquinolone- resistant uropathogen among renal transplant recipients

James R. Johnson, Brian Johnston, Connie Clabots, Michael A. Kuskowski, Swaroop Pendyala, Chitrita DeBroy, Bogdan Nowicki, James Rice

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54 Scopus citations

Abstract

Among 40 Escherichia coli urine isolates from renal transplant recipients (Galveston, TX, 2003 to 2005), sequence type ST131 (O25:H4) was highly prevalent (representing 35% of isolates overall and 60% of fluoroquinolone-resistant isolates), virulent appearing, antimicrobial resistant (but extended-spectrum- cephalosporin susceptible), and associated with black race. Pulsotypes were diverse; some were linked to other locales. ST131 emerged significantly during the study period. These findings suggest that E. coli ST131 may constitute an important new multidrug-resistant threat to renal transplant recipients.

Original languageEnglish (US)
Pages (from-to)546-550
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume54
Issue number1
DOIs
StatePublished - Jan 1 2010

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Johnson, J. R., Johnston, B., Clabots, C., Kuskowski, M. A., Pendyala, S., DeBroy, C., Nowicki, B., & Rice, J. (2010). Escherichia coli sequence type ST131 as an emerging fluoroquinolone- resistant uropathogen among renal transplant recipients. Antimicrobial agents and chemotherapy, 54(1), 546-550. https://doi.org/10.1128/AAC.01089-09