Esophageal and gastric motor abnormalities in gastroesophageal reflux during infancy

A. Craig Hillemeier, Bruce B. Grill, Richard McCallum, Joyce Gryboski

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Thirty-four infants with symptoms of gastroesophageal reflux were evaluated by esophageal manometry, pH probe, and gastric emptying studies. Infants with failure to thrive (group A) and recurrent pulmonary disease (group B) had more severe reflux by pH probe (41.6% and 36.3% reflux time postprandially, respectively) than the group of infants without serious sequellae of gastroesophageal reflux (group C), who had 19.0% reflux time postprandially, p < 0.01. Lower esophageal sphincter pressure did not vary significantly between infants with severe reflux and milder disease. Groups A and B had significantly decreased peristaltic amplitude in the distal body of the esophagus (28.3 ± 4.8 and 23.2 ± 5.5 mmHg, respectively) when compared to group C (50.2 ± 3.2 mm Hg, p < 0.01); in addition to a significantly increased number of nonperistaltic sequences. Gastric emptying of isotope-labeled cow's milk formula after 1 h was 20.9% and 22.8% in groups A and B, respectively; significantly delayed compared to 40.6% of the meal emptied in group C infants. Gastric retention was significantly correlated with impaired distal esophageal peristaltic amplitude (r = 0.68) and increased postprandial pH documented reflux (r = 0.60). Our results provide evidence for the diffuse nature of the upper gastrointestinal motility disorder present in severe gastroesophageal reflux of infancy.

Original languageEnglish (US)
Pages (from-to)741-746
Number of pages6
JournalGastroenterology
Volume84
Issue number4
StatePublished - 1983

Fingerprint

Gastroesophageal Reflux
Stomach
Gastric Emptying
Failure to Thrive
Lower Esophageal Sphincter
Gastrointestinal Motility
Manometry
Isotopes
Esophagus
Lung Diseases
Meals
Milk
Pressure

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Hillemeier, A. Craig ; Grill, Bruce B. ; McCallum, Richard ; Gryboski, Joyce. / Esophageal and gastric motor abnormalities in gastroesophageal reflux during infancy. In: Gastroenterology. 1983 ; Vol. 84, No. 4. pp. 741-746.
@article{dfbacc94b434464fbee888a7e9796655,
title = "Esophageal and gastric motor abnormalities in gastroesophageal reflux during infancy",
abstract = "Thirty-four infants with symptoms of gastroesophageal reflux were evaluated by esophageal manometry, pH probe, and gastric emptying studies. Infants with failure to thrive (group A) and recurrent pulmonary disease (group B) had more severe reflux by pH probe (41.6{\%} and 36.3{\%} reflux time postprandially, respectively) than the group of infants without serious sequellae of gastroesophageal reflux (group C), who had 19.0{\%} reflux time postprandially, p < 0.01. Lower esophageal sphincter pressure did not vary significantly between infants with severe reflux and milder disease. Groups A and B had significantly decreased peristaltic amplitude in the distal body of the esophagus (28.3 ± 4.8 and 23.2 ± 5.5 mmHg, respectively) when compared to group C (50.2 ± 3.2 mm Hg, p < 0.01); in addition to a significantly increased number of nonperistaltic sequences. Gastric emptying of isotope-labeled cow's milk formula after 1 h was 20.9{\%} and 22.8{\%} in groups A and B, respectively; significantly delayed compared to 40.6{\%} of the meal emptied in group C infants. Gastric retention was significantly correlated with impaired distal esophageal peristaltic amplitude (r = 0.68) and increased postprandial pH documented reflux (r = 0.60). Our results provide evidence for the diffuse nature of the upper gastrointestinal motility disorder present in severe gastroesophageal reflux of infancy.",
author = "Hillemeier, {A. Craig} and Grill, {Bruce B.} and Richard McCallum and Joyce Gryboski",
year = "1983",
language = "English (US)",
volume = "84",
pages = "741--746",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "4",

}

Hillemeier, AC, Grill, BB, McCallum, R & Gryboski, J 1983, 'Esophageal and gastric motor abnormalities in gastroesophageal reflux during infancy', Gastroenterology, vol. 84, no. 4, pp. 741-746.

Esophageal and gastric motor abnormalities in gastroesophageal reflux during infancy. / Hillemeier, A. Craig; Grill, Bruce B.; McCallum, Richard; Gryboski, Joyce.

In: Gastroenterology, Vol. 84, No. 4, 1983, p. 741-746.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Esophageal and gastric motor abnormalities in gastroesophageal reflux during infancy

AU - Hillemeier, A. Craig

AU - Grill, Bruce B.

AU - McCallum, Richard

AU - Gryboski, Joyce

PY - 1983

Y1 - 1983

N2 - Thirty-four infants with symptoms of gastroesophageal reflux were evaluated by esophageal manometry, pH probe, and gastric emptying studies. Infants with failure to thrive (group A) and recurrent pulmonary disease (group B) had more severe reflux by pH probe (41.6% and 36.3% reflux time postprandially, respectively) than the group of infants without serious sequellae of gastroesophageal reflux (group C), who had 19.0% reflux time postprandially, p < 0.01. Lower esophageal sphincter pressure did not vary significantly between infants with severe reflux and milder disease. Groups A and B had significantly decreased peristaltic amplitude in the distal body of the esophagus (28.3 ± 4.8 and 23.2 ± 5.5 mmHg, respectively) when compared to group C (50.2 ± 3.2 mm Hg, p < 0.01); in addition to a significantly increased number of nonperistaltic sequences. Gastric emptying of isotope-labeled cow's milk formula after 1 h was 20.9% and 22.8% in groups A and B, respectively; significantly delayed compared to 40.6% of the meal emptied in group C infants. Gastric retention was significantly correlated with impaired distal esophageal peristaltic amplitude (r = 0.68) and increased postprandial pH documented reflux (r = 0.60). Our results provide evidence for the diffuse nature of the upper gastrointestinal motility disorder present in severe gastroesophageal reflux of infancy.

AB - Thirty-four infants with symptoms of gastroesophageal reflux were evaluated by esophageal manometry, pH probe, and gastric emptying studies. Infants with failure to thrive (group A) and recurrent pulmonary disease (group B) had more severe reflux by pH probe (41.6% and 36.3% reflux time postprandially, respectively) than the group of infants without serious sequellae of gastroesophageal reflux (group C), who had 19.0% reflux time postprandially, p < 0.01. Lower esophageal sphincter pressure did not vary significantly between infants with severe reflux and milder disease. Groups A and B had significantly decreased peristaltic amplitude in the distal body of the esophagus (28.3 ± 4.8 and 23.2 ± 5.5 mmHg, respectively) when compared to group C (50.2 ± 3.2 mm Hg, p < 0.01); in addition to a significantly increased number of nonperistaltic sequences. Gastric emptying of isotope-labeled cow's milk formula after 1 h was 20.9% and 22.8% in groups A and B, respectively; significantly delayed compared to 40.6% of the meal emptied in group C infants. Gastric retention was significantly correlated with impaired distal esophageal peristaltic amplitude (r = 0.68) and increased postprandial pH documented reflux (r = 0.60). Our results provide evidence for the diffuse nature of the upper gastrointestinal motility disorder present in severe gastroesophageal reflux of infancy.

UR - http://www.scopus.com/inward/record.url?scp=0020696265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020696265&partnerID=8YFLogxK

M3 - Article

C2 - 6825985

AN - SCOPUS:0020696265

VL - 84

SP - 741

EP - 746

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 4

ER -