Essential fatty acids, prostaglandins, and respiratory distress syndrome of the newborn

Z. Friedman, L. M. Demers

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The lungs are a major metabolic site for the synthesis, release, and degradation of prostaglandins. Prostaglandins of the E and F series exert a potent physiological effect on the smooth muscle of blood vessels and the tracheobronchial tree; prostaglandin E dilates while prostaglandin F constricts. Thus, altered prostaglandin metabolism may contribute to the pathophysiology of respiratory distress syndrome (RDS). Twenty-one infants with RDS and ten age and weight-matched controls were studied by analyzing their plasma for prostaglandins and their precursor essential fatty acids. The two groups showed no difference in the essential fatty acid prostaglandin precursors, dihomo-γ-linolenic and arachidonic acids. During the acute phase of RDS, plasma levels of the primary prostaglandins E and F are significantly elevated compared with control values and the ratio of prostaglandin E to prostaglandin F significantly reduced. Prostaglandins E and F returned to control values on recovery from the acute stage of the disease. Two infants with persistent patent ductus arteriosus had significantly elevated prostaglandin E values in their plasma compared with controls. The elevated levels of circulating plasma prostaglandins E and F and the reversal of their ratio during the acute phase of RDS may have adverse pulmonary and multisystem effects.

Original languageEnglish (US)
Pages (from-to)341-347
Number of pages7
JournalPediatrics
Volume61
Issue number3
StatePublished - Jan 1 1978

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Newborn Respiratory Distress Syndrome
Essential Fatty Acids
Prostaglandins E
Prostaglandins F
Prostaglandins
Adult Respiratory Distress Syndrome
Linolenic Acids
Arachidonic Acids
Lung
Patent Ductus Arteriosus
Acute Disease
Smooth Muscle
Blood Vessels
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Friedman, Z. ; Demers, L. M. / Essential fatty acids, prostaglandins, and respiratory distress syndrome of the newborn. In: Pediatrics. 1978 ; Vol. 61, No. 3. pp. 341-347.
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Friedman, Z & Demers, LM 1978, 'Essential fatty acids, prostaglandins, and respiratory distress syndrome of the newborn', Pediatrics, vol. 61, no. 3, pp. 341-347.

Essential fatty acids, prostaglandins, and respiratory distress syndrome of the newborn. / Friedman, Z.; Demers, L. M.

In: Pediatrics, Vol. 61, No. 3, 01.01.1978, p. 341-347.

Research output: Contribution to journalArticle

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