Establishing the Role of PPARβ/δ in Carcinogenesis

Jeffrey M. Peters, Frank J. Gonzalez, Rolf Müller

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

The role of the nuclear hormone receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in carcinogenesis is controversial because conflicting studies indicate that it both inhibits and promotes tumorigenesis. In this review, we focus on recent studies on PPARβ/δ including the significance of increased or decreased PPARβ/δ expression in cancers; a range of opposing mechanisms describing how PPARβ/δ agonists, antagonists, and inverse agonists regulate tumorigenesis and/or whether there may be cell context-specific mechanisms; and whether activating or inhibiting PPARβ/δ is feasible for cancer chemoprevention and/or therapy. Research questions that need to be addressed are highlighted to establish whether PPARβ/δ can be effectively targeted for cancer chemoprevention.

Original languageEnglish (US)
Pages (from-to)595-607
Number of pages13
JournalTrends in Endocrinology and Metabolism
Volume26
Issue number11
DOIs
StatePublished - Nov 2015

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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