Establishment of a cottontail rabbit papillomavirus/HLA-A2.1 transgenic rabbit model

Jiafen Hu, Xuwen Peng, Lynn R. Budgeon, Nancy M. Cladel, Karla K. Balogh, Neil D. Christensen

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Three transgenic rabbit lines that express a well-characterized human major histocompatibility complex class I (MHC-I) gene (HLA-A2.1) have been established. All three lines carry the HLA-A2.1 heavy chain and are able to pass the transgene to their offspring with both the outbred and the inbred EIII/JC genetic background. HLA-A2.1 colocalizes exclusively with rabbit MHC-I on the cell surfaces. These HLA-A2.1 transgenic rabbits demonstrated infection patterns similar to those found after cottontail rabbit papillomavirus (CRPV) challenge when compared with results in normal rabbits, although higher regression rates were found in HLA-A2.1 transgenic rabbits. Because the CRPV genome can accommodate significant modifications, the CRPV/HLA-A2.1 rabbit model has the potential to be used to screen HLA-A2.1-restricted immunogenic epitopes from human papillomaviruses in the context of in vivo papillomavirus infection.

Original languageEnglish (US)
Pages (from-to)7171-7177
Number of pages7
JournalJournal of virology
Volume81
Issue number13
DOIs
StatePublished - Jul 2007

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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