Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort

Samuel Y. Ash, Gonzalo Vegas Sanchez-Ferrero, Mark L. Schiebler, Farbod N. Rahaghi, Ashish Rai, Carolyn E. Come, James C. Ross, Alysha G. Colon, Juan Carlos Cardet, Eugene R. Bleecker, Mario Castro, John V. Fahy, Sean B. Fain, Benjamin M. Gaston, Eric A. Hoffman, Nizar N. Jarjour, Jason K. Lempel, David T. Mauger, Matthew C. Tattersall, Sally E. WenzelBruce D. Levy, George R. Washko, Elliot Israel, Raul San Jose Estepar, Bruce Levy, George Washko, Manuela Cernadas, Wanda Phipatanakul, Sally Wenzel, Merritt Fajt, Benjamin Gaston, James Chmiel, W. Gerald Teague, Anne Marie Irani, Serpil Erzurum, Sumita Khatri, Suzy Comhair, Raed Dweik, Kristie Ross, Ross Myers, Wendy Moore, Deborah Meyers, Eugene Bleecker, Stephen Peters, Annette Hastie, Victor Ortega, Greg Hawkins, Xingan Li, Anne Fitzpatrick, Nazar Jarjour, Loren Denlinger, Sean Fain, Ronald Sorkness, Leonard Bacharier, David Gierada, Kenneth Schechtman, Jason Woods, John Fahy, Prescott Woodruff, Ngoc Ly, David Mauger

Research output: Contribution to journalArticle

Abstract

Background: Relative enlargement of the pulmonary artery (PA) on chest CT imaging is associated with respiratory exacerbations in patients with COPD or cystic fibrosis. We sought to determine whether similar findings were present in patients with asthma and whether these findings were explained by differences in ventricular size. Methods: We measured the PA and aorta diameters in 233 individuals from the Severe Asthma Research Program III cohort. We also estimated right, left, and total epicardial cardiac ventricular volume indices (eERVVI, eELVVI, and eETVVI, respectively). Associations between the cardiac and PA measures (PA-to-aorta [PA/A] ratio, eERVVI-to-eELVVI [eRV/eLV] ratio, eERVVI, eELVVI, eETVVI) and clinical measures of asthma severity were assessed by Pearson correlation, and associations with asthma severity and exacerbation rate were evaluated by multivariable linear and zero-inflated negative binomial regression. Results: Asthma severity was associated with smaller ventricular volumes. For example, those with severe asthma had 36.1 mL/m2 smaller eETVVI than healthy control subjects (P = .003) and 14.1 mL/m2 smaller eETVVI than those with mild/moderate disease (P = .011). Smaller ventricular volumes were also associated with a higher rate of asthma exacerbations, both retrospectively and prospectively. For example, those with an eETVVI less than the median had a 57% higher rate of exacerbations during follow-up than those with eETVVI greater than the median (P = .020). Neither PA/A nor eRV/eLV was associated with asthma severity or exacerbations. Conclusions: In patients with asthma, smaller cardiac ventricular size may be associated with more severe disease and a higher rate of asthma exacerbations. Trial Registry: ClinicalTrials.gov; No.: NCT01761630; URL: www.clinicaltrials.gov

Original languageEnglish (US)
Pages (from-to)258-267
Number of pages10
JournalCHEST
Volume157
Issue number2
DOIs
StatePublished - Feb 2020

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Asthma
Pulmonary Artery
Research
Aorta
Paroxysmal Dyspnea
Cardiac Volume
Cystic Fibrosis
Chronic Obstructive Pulmonary Disease
Registries
Healthy Volunteers
Thorax

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Ash, S. Y., Sanchez-Ferrero, G. V., Schiebler, M. L., Rahaghi, F. N., Rai, A., Come, C. E., ... Mauger, D. (2020). Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort. CHEST, 157(2), 258-267. https://doi.org/10.1016/j.chest.2019.08.2185
Ash, Samuel Y. ; Sanchez-Ferrero, Gonzalo Vegas ; Schiebler, Mark L. ; Rahaghi, Farbod N. ; Rai, Ashish ; Come, Carolyn E. ; Ross, James C. ; Colon, Alysha G. ; Cardet, Juan Carlos ; Bleecker, Eugene R. ; Castro, Mario ; Fahy, John V. ; Fain, Sean B. ; Gaston, Benjamin M. ; Hoffman, Eric A. ; Jarjour, Nizar N. ; Lempel, Jason K. ; Mauger, David T. ; Tattersall, Matthew C. ; Wenzel, Sally E. ; Levy, Bruce D. ; Washko, George R. ; Israel, Elliot ; San Jose Estepar, Raul ; Levy, Bruce ; Washko, George ; Cernadas, Manuela ; Phipatanakul, Wanda ; Wenzel, Sally ; Fajt, Merritt ; Gaston, Benjamin ; Chmiel, James ; Teague, W. Gerald ; Irani, Anne Marie ; Erzurum, Serpil ; Khatri, Sumita ; Comhair, Suzy ; Dweik, Raed ; Ross, Kristie ; Myers, Ross ; Moore, Wendy ; Meyers, Deborah ; Bleecker, Eugene ; Peters, Stephen ; Hastie, Annette ; Ortega, Victor ; Hawkins, Greg ; Li, Xingan ; Fitzpatrick, Anne ; Jarjour, Nazar ; Denlinger, Loren ; Fain, Sean ; Sorkness, Ronald ; Bacharier, Leonard ; Gierada, David ; Schechtman, Kenneth ; Woods, Jason ; Fahy, John ; Woodruff, Prescott ; Ly, Ngoc ; Mauger, David. / Estimated Ventricular Size, Asthma Severity, and Exacerbations : The Severe Asthma Research Program III Cohort. In: CHEST. 2020 ; Vol. 157, No. 2. pp. 258-267.
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abstract = "Background: Relative enlargement of the pulmonary artery (PA) on chest CT imaging is associated with respiratory exacerbations in patients with COPD or cystic fibrosis. We sought to determine whether similar findings were present in patients with asthma and whether these findings were explained by differences in ventricular size. Methods: We measured the PA and aorta diameters in 233 individuals from the Severe Asthma Research Program III cohort. We also estimated right, left, and total epicardial cardiac ventricular volume indices (eERVVI, eELVVI, and eETVVI, respectively). Associations between the cardiac and PA measures (PA-to-aorta [PA/A] ratio, eERVVI-to-eELVVI [eRV/eLV] ratio, eERVVI, eELVVI, eETVVI) and clinical measures of asthma severity were assessed by Pearson correlation, and associations with asthma severity and exacerbation rate were evaluated by multivariable linear and zero-inflated negative binomial regression. Results: Asthma severity was associated with smaller ventricular volumes. For example, those with severe asthma had 36.1 mL/m2 smaller eETVVI than healthy control subjects (P = .003) and 14.1 mL/m2 smaller eETVVI than those with mild/moderate disease (P = .011). Smaller ventricular volumes were also associated with a higher rate of asthma exacerbations, both retrospectively and prospectively. For example, those with an eETVVI less than the median had a 57{\%} higher rate of exacerbations during follow-up than those with eETVVI greater than the median (P = .020). Neither PA/A nor eRV/eLV was associated with asthma severity or exacerbations. Conclusions: In patients with asthma, smaller cardiac ventricular size may be associated with more severe disease and a higher rate of asthma exacerbations. Trial Registry: ClinicalTrials.gov; No.: NCT01761630; URL: www.clinicaltrials.gov",
author = "Ash, {Samuel Y.} and Sanchez-Ferrero, {Gonzalo Vegas} and Schiebler, {Mark L.} and Rahaghi, {Farbod N.} and Ashish Rai and Come, {Carolyn E.} and Ross, {James C.} and Colon, {Alysha G.} and Cardet, {Juan Carlos} and Bleecker, {Eugene R.} and Mario Castro and Fahy, {John V.} and Fain, {Sean B.} and Gaston, {Benjamin M.} and Hoffman, {Eric A.} and Jarjour, {Nizar N.} and Lempel, {Jason K.} and Mauger, {David T.} and Tattersall, {Matthew C.} and Wenzel, {Sally E.} and Levy, {Bruce D.} and Washko, {George R.} and Elliot Israel and {San Jose Estepar}, Raul and Bruce Levy and George Washko and Manuela Cernadas and Wanda Phipatanakul and Sally Wenzel and Merritt Fajt and Benjamin Gaston and James Chmiel and Teague, {W. Gerald} and Irani, {Anne Marie} and Serpil Erzurum and Sumita Khatri and Suzy Comhair and Raed Dweik and Kristie Ross and Ross Myers and Wendy Moore and Deborah Meyers and Eugene Bleecker and Stephen Peters and Annette Hastie and Victor Ortega and Greg Hawkins and Xingan Li and Anne Fitzpatrick and Nazar Jarjour and Loren Denlinger and Sean Fain and Ronald Sorkness and Leonard Bacharier and David Gierada and Kenneth Schechtman and Jason Woods and John Fahy and Prescott Woodruff and Ngoc Ly and David Mauger",
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Ash, SY, Sanchez-Ferrero, GV, Schiebler, ML, Rahaghi, FN, Rai, A, Come, CE, Ross, JC, Colon, AG, Cardet, JC, Bleecker, ER, Castro, M, Fahy, JV, Fain, SB, Gaston, BM, Hoffman, EA, Jarjour, NN, Lempel, JK, Mauger, DT, Tattersall, MC, Wenzel, SE, Levy, BD, Washko, GR, Israel, E, San Jose Estepar, R, Levy, B, Washko, G, Cernadas, M, Phipatanakul, W, Wenzel, S, Fajt, M, Gaston, B, Chmiel, J, Teague, WG, Irani, AM, Erzurum, S, Khatri, S, Comhair, S, Dweik, R, Ross, K, Myers, R, Moore, W, Meyers, D, Bleecker, E, Peters, S, Hastie, A, Ortega, V, Hawkins, G, Li, X, Fitzpatrick, A, Jarjour, N, Denlinger, L, Fain, S, Sorkness, R, Bacharier, L, Gierada, D, Schechtman, K, Woods, J, Fahy, J, Woodruff, P, Ly, N & Mauger, D 2020, 'Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort', CHEST, vol. 157, no. 2, pp. 258-267. https://doi.org/10.1016/j.chest.2019.08.2185

Estimated Ventricular Size, Asthma Severity, and Exacerbations : The Severe Asthma Research Program III Cohort. / Ash, Samuel Y.; Sanchez-Ferrero, Gonzalo Vegas; Schiebler, Mark L.; Rahaghi, Farbod N.; Rai, Ashish; Come, Carolyn E.; Ross, James C.; Colon, Alysha G.; Cardet, Juan Carlos; Bleecker, Eugene R.; Castro, Mario; Fahy, John V.; Fain, Sean B.; Gaston, Benjamin M.; Hoffman, Eric A.; Jarjour, Nizar N.; Lempel, Jason K.; Mauger, David T.; Tattersall, Matthew C.; Wenzel, Sally E.; Levy, Bruce D.; Washko, George R.; Israel, Elliot; San Jose Estepar, Raul; Levy, Bruce; Washko, George; Cernadas, Manuela; Phipatanakul, Wanda; Wenzel, Sally; Fajt, Merritt; Gaston, Benjamin; Chmiel, James; Teague, W. Gerald; Irani, Anne Marie; Erzurum, Serpil; Khatri, Sumita; Comhair, Suzy; Dweik, Raed; Ross, Kristie; Myers, Ross; Moore, Wendy; Meyers, Deborah; Bleecker, Eugene; Peters, Stephen; Hastie, Annette; Ortega, Victor; Hawkins, Greg; Li, Xingan; Fitzpatrick, Anne; Jarjour, Nazar; Denlinger, Loren; Fain, Sean; Sorkness, Ronald; Bacharier, Leonard; Gierada, David; Schechtman, Kenneth; Woods, Jason; Fahy, John; Woodruff, Prescott; Ly, Ngoc; Mauger, David.

In: CHEST, Vol. 157, No. 2, 02.2020, p. 258-267.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Estimated Ventricular Size, Asthma Severity, and Exacerbations

T2 - The Severe Asthma Research Program III Cohort

AU - Ash, Samuel Y.

AU - Sanchez-Ferrero, Gonzalo Vegas

AU - Schiebler, Mark L.

AU - Rahaghi, Farbod N.

AU - Rai, Ashish

AU - Come, Carolyn E.

AU - Ross, James C.

AU - Colon, Alysha G.

AU - Cardet, Juan Carlos

AU - Bleecker, Eugene R.

AU - Castro, Mario

AU - Fahy, John V.

AU - Fain, Sean B.

AU - Gaston, Benjamin M.

AU - Hoffman, Eric A.

AU - Jarjour, Nizar N.

AU - Lempel, Jason K.

AU - Mauger, David T.

AU - Tattersall, Matthew C.

AU - Wenzel, Sally E.

AU - Levy, Bruce D.

AU - Washko, George R.

AU - Israel, Elliot

AU - San Jose Estepar, Raul

AU - Levy, Bruce

AU - Washko, George

AU - Cernadas, Manuela

AU - Phipatanakul, Wanda

AU - Wenzel, Sally

AU - Fajt, Merritt

AU - Gaston, Benjamin

AU - Chmiel, James

AU - Teague, W. Gerald

AU - Irani, Anne Marie

AU - Erzurum, Serpil

AU - Khatri, Sumita

AU - Comhair, Suzy

AU - Dweik, Raed

AU - Ross, Kristie

AU - Myers, Ross

AU - Moore, Wendy

AU - Meyers, Deborah

AU - Bleecker, Eugene

AU - Peters, Stephen

AU - Hastie, Annette

AU - Ortega, Victor

AU - Hawkins, Greg

AU - Li, Xingan

AU - Fitzpatrick, Anne

AU - Jarjour, Nazar

AU - Denlinger, Loren

AU - Fain, Sean

AU - Sorkness, Ronald

AU - Bacharier, Leonard

AU - Gierada, David

AU - Schechtman, Kenneth

AU - Woods, Jason

AU - Fahy, John

AU - Woodruff, Prescott

AU - Ly, Ngoc

AU - Mauger, David

PY - 2020/2

Y1 - 2020/2

N2 - Background: Relative enlargement of the pulmonary artery (PA) on chest CT imaging is associated with respiratory exacerbations in patients with COPD or cystic fibrosis. We sought to determine whether similar findings were present in patients with asthma and whether these findings were explained by differences in ventricular size. Methods: We measured the PA and aorta diameters in 233 individuals from the Severe Asthma Research Program III cohort. We also estimated right, left, and total epicardial cardiac ventricular volume indices (eERVVI, eELVVI, and eETVVI, respectively). Associations between the cardiac and PA measures (PA-to-aorta [PA/A] ratio, eERVVI-to-eELVVI [eRV/eLV] ratio, eERVVI, eELVVI, eETVVI) and clinical measures of asthma severity were assessed by Pearson correlation, and associations with asthma severity and exacerbation rate were evaluated by multivariable linear and zero-inflated negative binomial regression. Results: Asthma severity was associated with smaller ventricular volumes. For example, those with severe asthma had 36.1 mL/m2 smaller eETVVI than healthy control subjects (P = .003) and 14.1 mL/m2 smaller eETVVI than those with mild/moderate disease (P = .011). Smaller ventricular volumes were also associated with a higher rate of asthma exacerbations, both retrospectively and prospectively. For example, those with an eETVVI less than the median had a 57% higher rate of exacerbations during follow-up than those with eETVVI greater than the median (P = .020). Neither PA/A nor eRV/eLV was associated with asthma severity or exacerbations. Conclusions: In patients with asthma, smaller cardiac ventricular size may be associated with more severe disease and a higher rate of asthma exacerbations. Trial Registry: ClinicalTrials.gov; No.: NCT01761630; URL: www.clinicaltrials.gov

AB - Background: Relative enlargement of the pulmonary artery (PA) on chest CT imaging is associated with respiratory exacerbations in patients with COPD or cystic fibrosis. We sought to determine whether similar findings were present in patients with asthma and whether these findings were explained by differences in ventricular size. Methods: We measured the PA and aorta diameters in 233 individuals from the Severe Asthma Research Program III cohort. We also estimated right, left, and total epicardial cardiac ventricular volume indices (eERVVI, eELVVI, and eETVVI, respectively). Associations between the cardiac and PA measures (PA-to-aorta [PA/A] ratio, eERVVI-to-eELVVI [eRV/eLV] ratio, eERVVI, eELVVI, eETVVI) and clinical measures of asthma severity were assessed by Pearson correlation, and associations with asthma severity and exacerbation rate were evaluated by multivariable linear and zero-inflated negative binomial regression. Results: Asthma severity was associated with smaller ventricular volumes. For example, those with severe asthma had 36.1 mL/m2 smaller eETVVI than healthy control subjects (P = .003) and 14.1 mL/m2 smaller eETVVI than those with mild/moderate disease (P = .011). Smaller ventricular volumes were also associated with a higher rate of asthma exacerbations, both retrospectively and prospectively. For example, those with an eETVVI less than the median had a 57% higher rate of exacerbations during follow-up than those with eETVVI greater than the median (P = .020). Neither PA/A nor eRV/eLV was associated with asthma severity or exacerbations. Conclusions: In patients with asthma, smaller cardiac ventricular size may be associated with more severe disease and a higher rate of asthma exacerbations. Trial Registry: ClinicalTrials.gov; No.: NCT01761630; URL: www.clinicaltrials.gov

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UR - http://www.scopus.com/inward/citedby.url?scp=85075447824&partnerID=8YFLogxK

U2 - 10.1016/j.chest.2019.08.2185

DO - 10.1016/j.chest.2019.08.2185

M3 - Article

C2 - 31521672

AN - SCOPUS:85075447824

VL - 157

SP - 258

EP - 267

JO - Chest

JF - Chest

SN - 0012-3692

IS - 2

ER -