Estimating rates of multiple gestation pregnancies: Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial

Michael P. Diamond, Mohamed Mitwally, Robert Casper, Joel Ager, Richard Legro, Robert Brzyski, Peter Casson, Esther Eisenberg, Heping Zhang

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Infertility afflicts 15% of couples who wish to conceive. Despite intensive evaluation of both male and female partners, the etiology may remain unknown leading to a diagnosis of unexplained infertility. For such couples, treatment often entails ovulation induction (OI) with fertility medications coupled with intrauterine insemination. Complications of this therapy include ovarian hyperstimulation syndrome and creation of multiple gestation pregnancies, which can be complicated by preterm labor and delivery, and the associated neonatal morbidity and expense of care for preterm infants. The Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) study is designed to assess whether OI in couples with unexplained infertility with an aromatase inhibitor produces mono-follicular development in most cycles, thereby reducing multiple gestations while maintaining a comparable pregnancy success rate to that achieved by OI with either gonadotropins or clomiphene citrate. These results will provide future guidance of therapy for couples with unexplained infertility, and if comparable pregnancy rates are achieved with a substantial reduction in multiple gestations, the public health benefit will be considerable.

Original languageEnglish (US)
Pages (from-to)902-908
Number of pages7
JournalContemporary Clinical Trials
Volume32
Issue number6
DOIs
StatePublished - Nov 1 2011

Fingerprint

Multiple Pregnancy
Ovulation Induction
Sample Size
Infertility
Pregnancy
Pregnancy Rate
Couples Therapy
Ovarian Hyperstimulation Syndrome
Clomiphene
Aromatase Inhibitors
Premature Obstetric Labor
Insemination
Insurance Benefits
Gonadotropins
Premature Infants
Fertility
Public Health
Morbidity
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Diamond, Michael P. ; Mitwally, Mohamed ; Casper, Robert ; Ager, Joel ; Legro, Richard ; Brzyski, Robert ; Casson, Peter ; Eisenberg, Esther ; Zhang, Heping. / Estimating rates of multiple gestation pregnancies : Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial. In: Contemporary Clinical Trials. 2011 ; Vol. 32, No. 6. pp. 902-908.
@article{62e608147b0043db91fe3a0b77e0e10c,
title = "Estimating rates of multiple gestation pregnancies: Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial",
abstract = "Infertility afflicts 15{\%} of couples who wish to conceive. Despite intensive evaluation of both male and female partners, the etiology may remain unknown leading to a diagnosis of unexplained infertility. For such couples, treatment often entails ovulation induction (OI) with fertility medications coupled with intrauterine insemination. Complications of this therapy include ovarian hyperstimulation syndrome and creation of multiple gestation pregnancies, which can be complicated by preterm labor and delivery, and the associated neonatal morbidity and expense of care for preterm infants. The Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) study is designed to assess whether OI in couples with unexplained infertility with an aromatase inhibitor produces mono-follicular development in most cycles, thereby reducing multiple gestations while maintaining a comparable pregnancy success rate to that achieved by OI with either gonadotropins or clomiphene citrate. These results will provide future guidance of therapy for couples with unexplained infertility, and if comparable pregnancy rates are achieved with a substantial reduction in multiple gestations, the public health benefit will be considerable.",
author = "Diamond, {Michael P.} and Mohamed Mitwally and Robert Casper and Joel Ager and Richard Legro and Robert Brzyski and Peter Casson and Esther Eisenberg and Heping Zhang",
year = "2011",
month = "11",
day = "1",
doi = "10.1016/j.cct.2011.07.009",
language = "English (US)",
volume = "32",
pages = "902--908",
journal = "Contemporary Clinical Trials",
issn = "1551-7144",
publisher = "Elsevier Inc.",
number = "6",

}

Estimating rates of multiple gestation pregnancies : Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial. / Diamond, Michael P.; Mitwally, Mohamed; Casper, Robert; Ager, Joel; Legro, Richard; Brzyski, Robert; Casson, Peter; Eisenberg, Esther; Zhang, Heping.

In: Contemporary Clinical Trials, Vol. 32, No. 6, 01.11.2011, p. 902-908.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Estimating rates of multiple gestation pregnancies

T2 - Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial

AU - Diamond, Michael P.

AU - Mitwally, Mohamed

AU - Casper, Robert

AU - Ager, Joel

AU - Legro, Richard

AU - Brzyski, Robert

AU - Casson, Peter

AU - Eisenberg, Esther

AU - Zhang, Heping

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Infertility afflicts 15% of couples who wish to conceive. Despite intensive evaluation of both male and female partners, the etiology may remain unknown leading to a diagnosis of unexplained infertility. For such couples, treatment often entails ovulation induction (OI) with fertility medications coupled with intrauterine insemination. Complications of this therapy include ovarian hyperstimulation syndrome and creation of multiple gestation pregnancies, which can be complicated by preterm labor and delivery, and the associated neonatal morbidity and expense of care for preterm infants. The Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) study is designed to assess whether OI in couples with unexplained infertility with an aromatase inhibitor produces mono-follicular development in most cycles, thereby reducing multiple gestations while maintaining a comparable pregnancy success rate to that achieved by OI with either gonadotropins or clomiphene citrate. These results will provide future guidance of therapy for couples with unexplained infertility, and if comparable pregnancy rates are achieved with a substantial reduction in multiple gestations, the public health benefit will be considerable.

AB - Infertility afflicts 15% of couples who wish to conceive. Despite intensive evaluation of both male and female partners, the etiology may remain unknown leading to a diagnosis of unexplained infertility. For such couples, treatment often entails ovulation induction (OI) with fertility medications coupled with intrauterine insemination. Complications of this therapy include ovarian hyperstimulation syndrome and creation of multiple gestation pregnancies, which can be complicated by preterm labor and delivery, and the associated neonatal morbidity and expense of care for preterm infants. The Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) study is designed to assess whether OI in couples with unexplained infertility with an aromatase inhibitor produces mono-follicular development in most cycles, thereby reducing multiple gestations while maintaining a comparable pregnancy success rate to that achieved by OI with either gonadotropins or clomiphene citrate. These results will provide future guidance of therapy for couples with unexplained infertility, and if comparable pregnancy rates are achieved with a substantial reduction in multiple gestations, the public health benefit will be considerable.

UR - http://www.scopus.com/inward/record.url?scp=80053383258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053383258&partnerID=8YFLogxK

U2 - 10.1016/j.cct.2011.07.009

DO - 10.1016/j.cct.2011.07.009

M3 - Article

C2 - 21787883

AN - SCOPUS:80053383258

VL - 32

SP - 902

EP - 908

JO - Contemporary Clinical Trials

JF - Contemporary Clinical Trials

SN - 1551-7144

IS - 6

ER -