Estimation of individual genetic and environmental profiles in longitudinal designs

Dorret I. Boomsma, Peter Molenaar, Conor V. Dolan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Parameter estimates obtained in the genetic analysis of longitudinal data can be used to construct individual genetic and environmental profiles across time. Such individual profiles enable the attribution of individual phenotypic change to changes in the underlying genetic or environmental processes and may lead to practical applications in genetic counseling and epidemiology. Simulations show that individual estimates of factor scores can be reliably obtained. Decomposition of univariate, and to a lesser extent of bivariate, phenotypic time series may yield estimates of independent individual G(t) and E(t), however, that are intercorrelated. The magnitude of these correlations depends somewhat on the autocorrelation structure of the underlying series, but to obtain completely independent estimates of genetic and environmental individual profiles, at least three measured indicators are needed at each point in time.

Original languageEnglish (US)
Pages (from-to)243-255
Number of pages13
JournalBehavior Genetics
Volume21
Issue number3
DOIs
StatePublished - May 1 1991

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Molecular Epidemiology
Genetic Counseling
counseling
genetic analysis
epidemiology
autocorrelation
genetic techniques and protocols
time series analysis
time series
decomposition
degradation
simulation
indicator
parameter

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Cite this

Boomsma, Dorret I. ; Molenaar, Peter ; Dolan, Conor V. / Estimation of individual genetic and environmental profiles in longitudinal designs. In: Behavior Genetics. 1991 ; Vol. 21, No. 3. pp. 243-255.
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Estimation of individual genetic and environmental profiles in longitudinal designs. / Boomsma, Dorret I.; Molenaar, Peter; Dolan, Conor V.

In: Behavior Genetics, Vol. 21, No. 3, 01.05.1991, p. 243-255.

Research output: Contribution to journalArticle

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