Estimation of Stratified Mark-Specific Proportional Hazards Models Under Two-Phase Sampling with Application to HIV Vaccine Efficacy Trials

Guangren Yang, Yanqing Sun, Li Qi, Peter B. Gilbert

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An objective of preventive HIV vaccine efficacy trials is to understand how vaccine-induced immune responses to specific protein sequences of HIV-1 associate with subsequent infection with specific sequences of HIV, where the immune response biomarkers are measured in vaccine recipients via a two-phase sampling design. Motivated by this objective, we investigate the stratified mark-specific proportional hazards model under two-phase biomarker sampling, where the mark is the genetic distance of an infecting HIV-1 sequence to an HIV-1 sequence represented inside the vaccine. Estimation and inference procedures based on inverse probability weighting of complete-cases and on augmented inverse probability weighting of complete-cases are developed. Asymptotic properties of the estimators are derived and their finite-sample performances are examined in simulation studies. The methods are shown to have satisfactory performance and are applied to the RV144 vaccine trial to assess whether immune response correlates of HIV-1 infection are stronger for HIV-1 infecting sequences similar to the vaccine than for sequences distant from the vaccine.

Original languageEnglish (US)
Pages (from-to)259-283
Number of pages25
JournalStatistics in Biosciences
Volume9
Issue number1
DOIs
StatePublished - Jun 1 2017

Fingerprint

Vaccine Efficacy
Two-phase Sampling
AIDS Vaccines
Proportional Hazards Model
Vaccine
Proportional Hazards Models
Hazards
Vaccines
HIV-1
Sampling
Immune Response
Inverse Probability Weighting
Biomarkers
Infection
Sampling Design
Protein Sequence
Correlate
Asymptotic Properties
HIV Infections
HIV

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Cite this

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Estimation of Stratified Mark-Specific Proportional Hazards Models Under Two-Phase Sampling with Application to HIV Vaccine Efficacy Trials. / Yang, Guangren; Sun, Yanqing; Qi, Li; Gilbert, Peter B.

In: Statistics in Biosciences, Vol. 9, No. 1, 01.06.2017, p. 259-283.

Research output: Contribution to journalArticle

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