Estradiol receptors in articular chondrocytes

Itzhak A. Rosner, Andrea Manni, Charles J. Malemud, Beata Boja, Roland W. Moskowitz

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Abstract

Recent experimental studies suggest a role for estrogens in chondrocyte metabolism and the development and treatment of osteoarthritis. Type I cytoplasmic estradiol receptors were found in articular chondrocytes. The presence of these receptors supports a possible mechanism for previous observations on estrogen suppressive effects on cartilage proteoglycan synthesis and offers a basis for further study on the role of estrogens in the physiology of cartilage and in the pathogenesis and treatment of osteoarthritis.

Original languageEnglish (US)
Pages (from-to)1378-1382
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume106
Issue number4
DOIs
StatePublished - Jun 30 1982

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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