Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats

Shawn G. Hayes, Nicolas B. Moya Del Pino, Marc P. Kaufman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Static exercise is well known to increase heart rate, arterial blood pressure, and ventilation. These increases appear to be less in women than in men, a difference that has been attributed to an effect of estrogen on neuronal function. In decerebrate male cats, we examined the effect of estrogen (17β-estradiol; 0.001, 0.01, 0.1, and 1.0 μg/kg iv) on the cardiovascular and ventilatory responses to central command and the exercise pressor reflex, the two neural mechanisms responsible for evoking the autonomic and ventilatory responses to exercise. We found that 17β-estradiol, in each of the three doses tested, attenuated the pressor, cardioaccelerator, and phrenic nerve responses to electrical stimulation of the mesencephalic locomotor region (i.e., central command). In contrast, none of the doses of 17β-estradiol had any effect on the pressor, cardioaccelerator, and ventilatory responses to static contraction or stretch of the triceps surae muscles. We conclude that, in decerebrate male cats, estrogen injected intravenously attenuates cardiovascular and ventilatory responses to central command but has no effect on responses to the exercise pressor reflex.

Original languageEnglish (US)
Pages (from-to)1635-1641
Number of pages7
JournalJournal of applied physiology
Volume92
Issue number4
DOIs
StatePublished - Jan 1 2002

Fingerprint

Estrogens
Cats
Exercise
Estradiol
Reflex
Phrenic Nerve
Electric Stimulation
Ventilation
Arterial Pressure
Heart Rate
Muscles

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

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abstract = "Static exercise is well known to increase heart rate, arterial blood pressure, and ventilation. These increases appear to be less in women than in men, a difference that has been attributed to an effect of estrogen on neuronal function. In decerebrate male cats, we examined the effect of estrogen (17β-estradiol; 0.001, 0.01, 0.1, and 1.0 μg/kg iv) on the cardiovascular and ventilatory responses to central command and the exercise pressor reflex, the two neural mechanisms responsible for evoking the autonomic and ventilatory responses to exercise. We found that 17β-estradiol, in each of the three doses tested, attenuated the pressor, cardioaccelerator, and phrenic nerve responses to electrical stimulation of the mesencephalic locomotor region (i.e., central command). In contrast, none of the doses of 17β-estradiol had any effect on the pressor, cardioaccelerator, and ventilatory responses to static contraction or stretch of the triceps surae muscles. We conclude that, in decerebrate male cats, estrogen injected intravenously attenuates cardiovascular and ventilatory responses to central command but has no effect on responses to the exercise pressor reflex.",
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Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats. / Hayes, Shawn G.; Moya Del Pino, Nicolas B.; Kaufman, Marc P.

In: Journal of applied physiology, Vol. 92, No. 4, 01.01.2002, p. 1635-1641.

Research output: Contribution to journalArticle

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