Ethanol

an enhancer of major histocompatibility complex antigen expression

L. J. Parent, R. Ehrlich, L. Matis, D. S. Singer

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Ethanol enhances expression of cell surface class I major histocompatibility complex (MHC) antigens in a variety of cell lines; up to an eightfold increase is observed in an embryonic cell line. In ethanol-treated L cells, increased cell surface expression of MHC antigens occurs with a concomitant increase in steady-state RNA levels. This effect is promoter dependent and restricted, because not all gene products are elevated. The effective ethanol concentration (1%) is physiologically attainable, leading to speculations about the role of elevated MHC antigens in alcohol-related diseases.

Original languageEnglish (US)
Pages (from-to)469-473
Number of pages5
JournalFASEB Journal
Volume1
Issue number6
StatePublished - 1987

Fingerprint

Histocompatibility Antigens
major histocompatibility complex
Major Histocompatibility Complex
Ethanol
ethanol
Cells
antigens
Antigens
cell lines
Cell Line
Histocompatibility Antigens Class I
cells
alcohols
Genes
promoter regions
Alcohols
RNA
genes

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Parent, L. J., Ehrlich, R., Matis, L., & Singer, D. S. (1987). Ethanol: an enhancer of major histocompatibility complex antigen expression. FASEB Journal, 1(6), 469-473.
Parent, L. J. ; Ehrlich, R. ; Matis, L. ; Singer, D. S. / Ethanol : an enhancer of major histocompatibility complex antigen expression. In: FASEB Journal. 1987 ; Vol. 1, No. 6. pp. 469-473.
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Parent, LJ, Ehrlich, R, Matis, L & Singer, DS 1987, 'Ethanol: an enhancer of major histocompatibility complex antigen expression', FASEB Journal, vol. 1, no. 6, pp. 469-473.

Ethanol : an enhancer of major histocompatibility complex antigen expression. / Parent, L. J.; Ehrlich, R.; Matis, L.; Singer, D. S.

In: FASEB Journal, Vol. 1, No. 6, 1987, p. 469-473.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ethanol

T2 - an enhancer of major histocompatibility complex antigen expression

AU - Parent, L. J.

AU - Ehrlich, R.

AU - Matis, L.

AU - Singer, D. S.

PY - 1987

Y1 - 1987

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M3 - Article

VL - 1

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JF - FASEB Journal

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