Ethanol: an enhancer of major histocompatibility complex antigen expression

L. J. Parent, R. Ehrlich, L. Matis, D. S. Singer

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Abstract

Ethanol enhances expression of cell surface class I major histocompatibility complex (MHC) antigens in a variety of cell lines; up to an eightfold increase is observed in an embryonic cell line. In ethanol-treated L cells, increased cell surface expression of MHC antigens occurs with a concomitant increase in steady-state RNA levels. This effect is promoter dependent and restricted, because not all gene products are elevated. The effective ethanol concentration (1%) is physiologically attainable, leading to speculations about the role of elevated MHC antigens in alcohol-related diseases.

Original languageEnglish (US)
Pages (from-to)469-473
Number of pages5
JournalFASEB Journal
Volume1
Issue number6
Publication statusPublished - Dec 1 1987

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Parent, L. J., Ehrlich, R., Matis, L., & Singer, D. S. (1987). Ethanol: an enhancer of major histocompatibility complex antigen expression. FASEB Journal, 1(6), 469-473.