Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians

Dingyan Chen, Li Liu, Yang Xiao, Yuehua Peng, Chengwu Yang, Zengzhen Wang

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Background: Many studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results were inconsistent. To better understand this relationship, ethnicity-specific meta-analyses were conducted. Methods: We retrieved all eligible studies published up to April 12, 2011 from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases. Ethnicity-specific meta-analyses were performed using either fixed- or random-effect models as appropriate. Results: Twelve independent studies with 1900 cases and 2382 controls were included. Five studies were conducted in Asians and seven in Caucasians. Ethnicity-specific meta-analyses revealed that the A118G polymorphism was significantly associated with alcohol dependence risk in Asians (GA vs. AA: odds ratio [OR], 1.73; 95% confidence interval [CI], 1.33-2.25; GA + GG vs. AA: OR, 1.57; 95% CI, 1.22-2.02), but not in Caucasians (GA vs. AA: OR, 1.05; 95% CI, 0.75-1.49; GA + GG vs. AA: OR, 1.11; 95% CI, 0.79-1.55). Conclusions: The OPRM1 A118G polymorphism may contribute to the susceptibility of alcohol dependence in Asians but not in Caucasians.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalDrug and alcohol dependence
Volume123
Issue number1-3
DOIs
StatePublished - Jun 1 2012

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Polymorphism
Alcoholism
Meta-Analysis
Odds Ratio
Alcohols
Confidence Intervals
PubMed
MEDLINE
Databases

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Chen, Dingyan ; Liu, Li ; Xiao, Yang ; Peng, Yuehua ; Yang, Chengwu ; Wang, Zengzhen. / Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians. In: Drug and alcohol dependence. 2012 ; Vol. 123, No. 1-3. pp. 1-6.
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abstract = "Background: Many studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results were inconsistent. To better understand this relationship, ethnicity-specific meta-analyses were conducted. Methods: We retrieved all eligible studies published up to April 12, 2011 from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases. Ethnicity-specific meta-analyses were performed using either fixed- or random-effect models as appropriate. Results: Twelve independent studies with 1900 cases and 2382 controls were included. Five studies were conducted in Asians and seven in Caucasians. Ethnicity-specific meta-analyses revealed that the A118G polymorphism was significantly associated with alcohol dependence risk in Asians (GA vs. AA: odds ratio [OR], 1.73; 95{\%} confidence interval [CI], 1.33-2.25; GA + GG vs. AA: OR, 1.57; 95{\%} CI, 1.22-2.02), but not in Caucasians (GA vs. AA: OR, 1.05; 95{\%} CI, 0.75-1.49; GA + GG vs. AA: OR, 1.11; 95{\%} CI, 0.79-1.55). Conclusions: The OPRM1 A118G polymorphism may contribute to the susceptibility of alcohol dependence in Asians but not in Caucasians.",
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Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians. / Chen, Dingyan; Liu, Li; Xiao, Yang; Peng, Yuehua; Yang, Chengwu; Wang, Zengzhen.

In: Drug and alcohol dependence, Vol. 123, No. 1-3, 01.06.2012, p. 1-6.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians

AU - Chen, Dingyan

AU - Liu, Li

AU - Xiao, Yang

AU - Peng, Yuehua

AU - Yang, Chengwu

AU - Wang, Zengzhen

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Background: Many studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results were inconsistent. To better understand this relationship, ethnicity-specific meta-analyses were conducted. Methods: We retrieved all eligible studies published up to April 12, 2011 from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases. Ethnicity-specific meta-analyses were performed using either fixed- or random-effect models as appropriate. Results: Twelve independent studies with 1900 cases and 2382 controls were included. Five studies were conducted in Asians and seven in Caucasians. Ethnicity-specific meta-analyses revealed that the A118G polymorphism was significantly associated with alcohol dependence risk in Asians (GA vs. AA: odds ratio [OR], 1.73; 95% confidence interval [CI], 1.33-2.25; GA + GG vs. AA: OR, 1.57; 95% CI, 1.22-2.02), but not in Caucasians (GA vs. AA: OR, 1.05; 95% CI, 0.75-1.49; GA + GG vs. AA: OR, 1.11; 95% CI, 0.79-1.55). Conclusions: The OPRM1 A118G polymorphism may contribute to the susceptibility of alcohol dependence in Asians but not in Caucasians.

AB - Background: Many studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results were inconsistent. To better understand this relationship, ethnicity-specific meta-analyses were conducted. Methods: We retrieved all eligible studies published up to April 12, 2011 from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases. Ethnicity-specific meta-analyses were performed using either fixed- or random-effect models as appropriate. Results: Twelve independent studies with 1900 cases and 2382 controls were included. Five studies were conducted in Asians and seven in Caucasians. Ethnicity-specific meta-analyses revealed that the A118G polymorphism was significantly associated with alcohol dependence risk in Asians (GA vs. AA: odds ratio [OR], 1.73; 95% confidence interval [CI], 1.33-2.25; GA + GG vs. AA: OR, 1.57; 95% CI, 1.22-2.02), but not in Caucasians (GA vs. AA: OR, 1.05; 95% CI, 0.75-1.49; GA + GG vs. AA: OR, 1.11; 95% CI, 0.79-1.55). Conclusions: The OPRM1 A118G polymorphism may contribute to the susceptibility of alcohol dependence in Asians but not in Caucasians.

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JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

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