Ethnically mismatched cord blood transplants in African Americans

The Saint Louis Cord Blood Bank experience

J. D. Wofford, J. Kemp, D. Regan, Michael Creer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: For ethnic minority patients where a suitably matched BM or peripheral blood donor is frequently unavailable, cord blood offers an opportunity for hematopoietic stem cell transplantation. Focused recruitment of ethnic minorities for cord blood donation has been proposed as the preferred strategy to improve access for minority recipients to cord blood for transplantation. The aim of this study was to evaluate cord blood characteristics for Caucasian and African American donors and the success of ethnically mismatched UC blood transplantation in African American recipients. Methods: Retrospective data analysis was performed comparing the characteristics of 556 cord blood units from African American and Caucasian donors. The outcomes of 18 African American ethnically mismatched transplant recipients were compared with a paired sample of 18 ethnically matched Caucasian recipients. Results: The fraction of collected units meeting acceptability criteria from African Americans was significantly lower compared with Caucasians (P = 0.0001). Additionally, African Americans had a significantly lower post-processing total nucleated cell count (TNC) compared with Caucasians (P = 0.007) but there were no other significant differences in conventionally measured product characteristics. In the transplant analysis, there was no difference in overall survival at 1 year (P = 0.85) or time to neutrophil engraftment (P = 0.92) between the two patient populations. Discussion: At comparable levels of TNC dose and HLA matching, the use of ethnically mismatched UC blood units as a source for allogeneic unrelated transplant can result in successful transplant outcomes for African American patients.

Original languageEnglish (US)
Pages (from-to)660-666
Number of pages7
JournalCytotherapy
Volume9
Issue number7
DOIs
StatePublished - Oct 25 2007

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Blood Banks
Fetal Blood
African Americans
Transplants
Blood Donors
Cell Count
Transplantation
Tissue Donors
Hematopoietic Stem Cell Transplantation
Neutrophils
Survival
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Genetics(clinical)
  • Cell Biology
  • Transplantation
  • Cancer Research

Cite this

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title = "Ethnically mismatched cord blood transplants in African Americans: The Saint Louis Cord Blood Bank experience",
abstract = "Background: For ethnic minority patients where a suitably matched BM or peripheral blood donor is frequently unavailable, cord blood offers an opportunity for hematopoietic stem cell transplantation. Focused recruitment of ethnic minorities for cord blood donation has been proposed as the preferred strategy to improve access for minority recipients to cord blood for transplantation. The aim of this study was to evaluate cord blood characteristics for Caucasian and African American donors and the success of ethnically mismatched UC blood transplantation in African American recipients. Methods: Retrospective data analysis was performed comparing the characteristics of 556 cord blood units from African American and Caucasian donors. The outcomes of 18 African American ethnically mismatched transplant recipients were compared with a paired sample of 18 ethnically matched Caucasian recipients. Results: The fraction of collected units meeting acceptability criteria from African Americans was significantly lower compared with Caucasians (P = 0.0001). Additionally, African Americans had a significantly lower post-processing total nucleated cell count (TNC) compared with Caucasians (P = 0.007) but there were no other significant differences in conventionally measured product characteristics. In the transplant analysis, there was no difference in overall survival at 1 year (P = 0.85) or time to neutrophil engraftment (P = 0.92) between the two patient populations. Discussion: At comparable levels of TNC dose and HLA matching, the use of ethnically mismatched UC blood units as a source for allogeneic unrelated transplant can result in successful transplant outcomes for African American patients.",
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Ethnically mismatched cord blood transplants in African Americans : The Saint Louis Cord Blood Bank experience. / Wofford, J. D.; Kemp, J.; Regan, D.; Creer, Michael.

In: Cytotherapy, Vol. 9, No. 7, 25.10.2007, p. 660-666.

Research output: Contribution to journalArticle

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