Evaluating associations between vaccine response and malnutrition, gut function, and enteric infections in the MAL-ED cohort study

Methods and challenges

The MAL-ED Network Investigators

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Most vaccine assessments have occurred in well-nourished populations of higher socioeconomic status. However, vaccines are often used in populations with high incidences of malnutrition and infections, in whom the effectiveness of some vaccines is inferior for unknown reasons. The degree and extent of vaccine underperformance have not been systematically studied for most vaccines across differing epidemiologic settings. This paper outlines the methods used and challenges associated with measuring immunological responses to oral vaccines against poliovirus and rotavirus, and parenteral vaccines against pertussis, tetanus, and measles in an observational study that monitored daily illness, monthly growth, intestinal inflammation and permeability, pathogen burden, dietary intake, and micronutrient status in children in 8 countries. This evaluation of vaccine response in the context of low- and middle-income countries is intended to address the gaps in knowledge of the heterogeneity in vaccine response in diverse epidemiological settings and the interplay between infections, nutrition, and immune response.

Original languageEnglish (US)
Pages (from-to)S273-S279
JournalClinical Infectious Diseases
Volume59
DOIs
StatePublished - Nov 1 2014

Fingerprint

Malnutrition
Cohort Studies
Vaccines
Infection
Oral Poliovirus Vaccine
Rotavirus Vaccines
Whooping Cough
Micronutrients
Tetanus
Measles
Social Class
Population
Observational Studies
Permeability
Inflammation
Incidence
Growth

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{38dfdf6fbb2f40a3a8e3fe71a9bcd337,
title = "Evaluating associations between vaccine response and malnutrition, gut function, and enteric infections in the MAL-ED cohort study: Methods and challenges",
abstract = "Most vaccine assessments have occurred in well-nourished populations of higher socioeconomic status. However, vaccines are often used in populations with high incidences of malnutrition and infections, in whom the effectiveness of some vaccines is inferior for unknown reasons. The degree and extent of vaccine underperformance have not been systematically studied for most vaccines across differing epidemiologic settings. This paper outlines the methods used and challenges associated with measuring immunological responses to oral vaccines against poliovirus and rotavirus, and parenteral vaccines against pertussis, tetanus, and measles in an observational study that monitored daily illness, monthly growth, intestinal inflammation and permeability, pathogen burden, dietary intake, and micronutrient status in children in 8 countries. This evaluation of vaccine response in the context of low- and middle-income countries is intended to address the gaps in knowledge of the heterogeneity in vaccine response in diverse epidemiological settings and the interplay between infections, nutrition, and immune response.",
author = "{The MAL-ED Network Investigators} and Christel Hoest and Seidman, {Jessica C.} and William Pan and Ramya Ambikapathi and Gagandeep Kang and Margaret Kosek and Stacey Knobler and Mason, {Carl J.} and Mark Miller and Acosta, {Angel Mendez} and Chavez, {Cesar Banda} and Flores, {Julian Torres} and Olotegui, {Maribel Paredes} and Pinedo, {Silvia Rengifo} and Trigoso, {Dixner Rengifo} and Vasquez, {Angel Orbe} and Imran Ahmed and Didar Alam and Asad Ali and Bhutta, {Zulfiqar A.} and Shahida Qureshi and Sadia Shakoor and Sajid Soofi and Ali Turab and Yousafzai, {Aisha K.} and Zaidi, {Anita K.M.} and Ladaporn Bodhidatta and Sudhir Babji and Anuradha Bose and Sushil John and Beena Kurien and Jayaprakash Muliyil and Raghava, {Mohan Venkata} and Anup Ramachandran and Anuradha Rose and Danny Carreon and Vivek Charu and Leyfou Dabo and Viyada Doan and Jhanelle Graham and Dennis Lang and McCormick Benjamin and Monica McGrath and Archana Mohale and Gaurvika Nayyar and Stephanie Psaki and Zeba Rasmussen and Stephanie Richard and Murray-Kolb, {Laura E.} and Barbara Schaefer",
year = "2014",
month = "11",
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language = "English (US)",
volume = "59",
pages = "S273--S279",
journal = "Clinical Infectious Diseases",
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Evaluating associations between vaccine response and malnutrition, gut function, and enteric infections in the MAL-ED cohort study : Methods and challenges. / The MAL-ED Network Investigators.

In: Clinical Infectious Diseases, Vol. 59, 01.11.2014, p. S273-S279.

Research output: Contribution to journalArticle

TY - JOUR

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AU - The MAL-ED Network Investigators

AU - Hoest, Christel

AU - Seidman, Jessica C.

AU - Pan, William

AU - Ambikapathi, Ramya

AU - Kang, Gagandeep

AU - Kosek, Margaret

AU - Knobler, Stacey

AU - Mason, Carl J.

AU - Miller, Mark

AU - Acosta, Angel Mendez

AU - Chavez, Cesar Banda

AU - Flores, Julian Torres

AU - Olotegui, Maribel Paredes

AU - Pinedo, Silvia Rengifo

AU - Trigoso, Dixner Rengifo

AU - Vasquez, Angel Orbe

AU - Ahmed, Imran

AU - Alam, Didar

AU - Ali, Asad

AU - Bhutta, Zulfiqar A.

AU - Qureshi, Shahida

AU - Shakoor, Sadia

AU - Soofi, Sajid

AU - Turab, Ali

AU - Yousafzai, Aisha K.

AU - Zaidi, Anita K.M.

AU - Bodhidatta, Ladaporn

AU - Babji, Sudhir

AU - Bose, Anuradha

AU - John, Sushil

AU - Kurien, Beena

AU - Muliyil, Jayaprakash

AU - Raghava, Mohan Venkata

AU - Ramachandran, Anup

AU - Rose, Anuradha

AU - Carreon, Danny

AU - Charu, Vivek

AU - Dabo, Leyfou

AU - Doan, Viyada

AU - Graham, Jhanelle

AU - Lang, Dennis

AU - Benjamin, McCormick

AU - McGrath, Monica

AU - Mohale, Archana

AU - Nayyar, Gaurvika

AU - Psaki, Stephanie

AU - Rasmussen, Zeba

AU - Richard, Stephanie

AU - Murray-Kolb, Laura E.

AU - Schaefer, Barbara

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