Evaluation and treatment of Cryptorchidism: AUA guideline

Thomas F. Kolon, C. D.Anthony Herndon, Linda A. Baker, Laurence S. Baskin, Cheryl G. Baxter, Earl Y. Cheng, Mireya Diaz, Peter A. Lee, Carl J. Seashore, Gregory E. Tasian, Julia S. Barthold

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Purpose Cryptorchidism is one of the most common pediatric disorders of the male endocrine glands and the most common genital disorder identified at birth. This guideline is intended to provide physicians and non-physician providers (primary care and specialists) with a consensus of principles and treatment plans for the management of cryptorchidism (typically isolated non-syndromic). Materials and Methods A systematic review and meta-analysis of the published literature was conducted using controlled vocabulary supplemented with key words relating to the relevant concepts of cryptorchidism. The search strategy was developed and executed by reference librarians and methodologists to create an evidence report limited to English-language, published peer-reviewed literature. This review yielded 704 articles published from 1980 through 2013 that were used to form a majority of the guideline statements. Clinical Principles and Expert Opinions were used for guideline statements lacking sufficient evidence-based data. Results Guideline statements were created to inform clinicians on the proper methods of history-taking, physical exam, and evaluation of the boy with cryptorchidism, as well as the various hormonal and surgical treatment options. Conclusions Imaging for cryptorchidism is not recommended prior to referral, which should occur by 6 months of age. Orchidopexy (orchiopexy is the preferred term) is the most successful therapy to relocate the testis into the scrotum, while hormonal therapy is not recommended. Successful scrotal repositioning of the testis may reduce but does not prevent the potential long-term issues of infertility and testis cancer. Appropriate counseling and follow-up of the patient is essential.

Original languageEnglish (US)
Pages (from-to)337-345
Number of pages9
JournalJournal of Urology
Volume192
Issue number2
DOIs
StatePublished - Aug 2014

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Cryptorchidism
Guidelines
Orchiopexy
Testis
Controlled Vocabulary
Librarians
Endocrine Glands
Therapeutics
Scrotum
Testicular Neoplasms
Expert Testimony
Infertility
Meta-Analysis
Counseling
Primary Health Care
Consensus
Language
Referral and Consultation
History
Parturition

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Kolon, T. F., Herndon, C. D. A., Baker, L. A., Baskin, L. S., Baxter, C. G., Cheng, E. Y., ... Barthold, J. S. (2014). Evaluation and treatment of Cryptorchidism: AUA guideline. Journal of Urology, 192(2), 337-345. https://doi.org/10.1016/j.juro.2014.05.005
Kolon, Thomas F. ; Herndon, C. D.Anthony ; Baker, Linda A. ; Baskin, Laurence S. ; Baxter, Cheryl G. ; Cheng, Earl Y. ; Diaz, Mireya ; Lee, Peter A. ; Seashore, Carl J. ; Tasian, Gregory E. ; Barthold, Julia S. / Evaluation and treatment of Cryptorchidism : AUA guideline. In: Journal of Urology. 2014 ; Vol. 192, No. 2. pp. 337-345.
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Kolon, TF, Herndon, CDA, Baker, LA, Baskin, LS, Baxter, CG, Cheng, EY, Diaz, M, Lee, PA, Seashore, CJ, Tasian, GE & Barthold, JS 2014, 'Evaluation and treatment of Cryptorchidism: AUA guideline', Journal of Urology, vol. 192, no. 2, pp. 337-345. https://doi.org/10.1016/j.juro.2014.05.005

Evaluation and treatment of Cryptorchidism : AUA guideline. / Kolon, Thomas F.; Herndon, C. D.Anthony; Baker, Linda A.; Baskin, Laurence S.; Baxter, Cheryl G.; Cheng, Earl Y.; Diaz, Mireya; Lee, Peter A.; Seashore, Carl J.; Tasian, Gregory E.; Barthold, Julia S.

In: Journal of Urology, Vol. 192, No. 2, 08.2014, p. 337-345.

Research output: Contribution to journalArticle

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AU - Kolon, Thomas F.

AU - Herndon, C. D.Anthony

AU - Baker, Linda A.

AU - Baskin, Laurence S.

AU - Baxter, Cheryl G.

AU - Cheng, Earl Y.

AU - Diaz, Mireya

AU - Lee, Peter A.

AU - Seashore, Carl J.

AU - Tasian, Gregory E.

AU - Barthold, Julia S.

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N2 - Purpose Cryptorchidism is one of the most common pediatric disorders of the male endocrine glands and the most common genital disorder identified at birth. This guideline is intended to provide physicians and non-physician providers (primary care and specialists) with a consensus of principles and treatment plans for the management of cryptorchidism (typically isolated non-syndromic). Materials and Methods A systematic review and meta-analysis of the published literature was conducted using controlled vocabulary supplemented with key words relating to the relevant concepts of cryptorchidism. The search strategy was developed and executed by reference librarians and methodologists to create an evidence report limited to English-language, published peer-reviewed literature. This review yielded 704 articles published from 1980 through 2013 that were used to form a majority of the guideline statements. Clinical Principles and Expert Opinions were used for guideline statements lacking sufficient evidence-based data. Results Guideline statements were created to inform clinicians on the proper methods of history-taking, physical exam, and evaluation of the boy with cryptorchidism, as well as the various hormonal and surgical treatment options. Conclusions Imaging for cryptorchidism is not recommended prior to referral, which should occur by 6 months of age. Orchidopexy (orchiopexy is the preferred term) is the most successful therapy to relocate the testis into the scrotum, while hormonal therapy is not recommended. Successful scrotal repositioning of the testis may reduce but does not prevent the potential long-term issues of infertility and testis cancer. Appropriate counseling and follow-up of the patient is essential.

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Kolon TF, Herndon CDA, Baker LA, Baskin LS, Baxter CG, Cheng EY et al. Evaluation and treatment of Cryptorchidism: AUA guideline. Journal of Urology. 2014 Aug;192(2):337-345. https://doi.org/10.1016/j.juro.2014.05.005