Evaluation of neonatal exposure to cocaine on learning, activity, startle, scent marking, immobility, and plasma cocaine concentrations

Charles V. Vorhees, Sandra L. Inman-Wood, Laronda L. Morford, Tracy M. Reed, Mary S. Moran, Cunfeng Pu, Gregg D. Cappon

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Prenatal cocaine treatment produces equivocal effects on spatial learning and memory; however, no data are available on neonatal treatment as a model of human third-trimester exposure. Sprague-Dawley rats were treated on postnatal days (P) 1-10 or 11-20 with cocaine (15 mg/kg x 4 per day at 2-h intervals) or saline (P1-P20) and evaluated as adults in the Morris water maze and on tests of activity, startle, scent marking, swimming immobility, and sequential learning. Neonatal cocaine had no effect on mortality; however, early treatment reduced body weight, whereas later treatment did not. Neonatal cocaine had no effects on exploratory activity, swimming ability, sequential learning, multiday activity rhythms, scent marking, or swimming immobility, but augmented acoustic startle amplitude in the early-treated group. Neonatal cocaine also produced an interaction on spatial learning in which the cocaine early-treated males performed slightly more efficiently than controls. Plasma cocaine concentrations were significantly higher in the early-treated group than the later-treated group despite receiving the same weight-adjusted doses. It was concluded that neonatal cocaine, when administered during a stage of brain development analogous to human third trimester, induces few behavioral effects based on the assessments used in this study. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)255-265
Number of pages11
JournalNeurotoxicology and Teratology
Volume22
Issue number2
DOIs
StatePublished - Jan 1 2000

Fingerprint

Cocaine
Learning
Plasmas
Third Pregnancy Trimester
Aptitude
Acoustics
Sprague Dawley Rats
Rats
Brain
Body Weight
Data storage equipment
Weights and Measures
Mortality
Water
Swimming

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Vorhees, Charles V. ; Inman-Wood, Sandra L. ; Morford, Laronda L. ; Reed, Tracy M. ; Moran, Mary S. ; Pu, Cunfeng ; Cappon, Gregg D. / Evaluation of neonatal exposure to cocaine on learning, activity, startle, scent marking, immobility, and plasma cocaine concentrations. In: Neurotoxicology and Teratology. 2000 ; Vol. 22, No. 2. pp. 255-265.
@article{2e3d4bc5fdd94815a6928c6fa44a0d1c,
title = "Evaluation of neonatal exposure to cocaine on learning, activity, startle, scent marking, immobility, and plasma cocaine concentrations",
abstract = "Prenatal cocaine treatment produces equivocal effects on spatial learning and memory; however, no data are available on neonatal treatment as a model of human third-trimester exposure. Sprague-Dawley rats were treated on postnatal days (P) 1-10 or 11-20 with cocaine (15 mg/kg x 4 per day at 2-h intervals) or saline (P1-P20) and evaluated as adults in the Morris water maze and on tests of activity, startle, scent marking, swimming immobility, and sequential learning. Neonatal cocaine had no effect on mortality; however, early treatment reduced body weight, whereas later treatment did not. Neonatal cocaine had no effects on exploratory activity, swimming ability, sequential learning, multiday activity rhythms, scent marking, or swimming immobility, but augmented acoustic startle amplitude in the early-treated group. Neonatal cocaine also produced an interaction on spatial learning in which the cocaine early-treated males performed slightly more efficiently than controls. Plasma cocaine concentrations were significantly higher in the early-treated group than the later-treated group despite receiving the same weight-adjusted doses. It was concluded that neonatal cocaine, when administered during a stage of brain development analogous to human third trimester, induces few behavioral effects based on the assessments used in this study. Copyright (C) 2000 Elsevier Science Inc.",
author = "Vorhees, {Charles V.} and Inman-Wood, {Sandra L.} and Morford, {Laronda L.} and Reed, {Tracy M.} and Moran, {Mary S.} and Cunfeng Pu and Cappon, {Gregg D.}",
year = "2000",
month = "1",
day = "1",
doi = "10.1016/S0892-0362(99)00071-9",
language = "English (US)",
volume = "22",
pages = "255--265",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc.",
number = "2",

}

Evaluation of neonatal exposure to cocaine on learning, activity, startle, scent marking, immobility, and plasma cocaine concentrations. / Vorhees, Charles V.; Inman-Wood, Sandra L.; Morford, Laronda L.; Reed, Tracy M.; Moran, Mary S.; Pu, Cunfeng; Cappon, Gregg D.

In: Neurotoxicology and Teratology, Vol. 22, No. 2, 01.01.2000, p. 255-265.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of neonatal exposure to cocaine on learning, activity, startle, scent marking, immobility, and plasma cocaine concentrations

AU - Vorhees, Charles V.

AU - Inman-Wood, Sandra L.

AU - Morford, Laronda L.

AU - Reed, Tracy M.

AU - Moran, Mary S.

AU - Pu, Cunfeng

AU - Cappon, Gregg D.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Prenatal cocaine treatment produces equivocal effects on spatial learning and memory; however, no data are available on neonatal treatment as a model of human third-trimester exposure. Sprague-Dawley rats were treated on postnatal days (P) 1-10 or 11-20 with cocaine (15 mg/kg x 4 per day at 2-h intervals) or saline (P1-P20) and evaluated as adults in the Morris water maze and on tests of activity, startle, scent marking, swimming immobility, and sequential learning. Neonatal cocaine had no effect on mortality; however, early treatment reduced body weight, whereas later treatment did not. Neonatal cocaine had no effects on exploratory activity, swimming ability, sequential learning, multiday activity rhythms, scent marking, or swimming immobility, but augmented acoustic startle amplitude in the early-treated group. Neonatal cocaine also produced an interaction on spatial learning in which the cocaine early-treated males performed slightly more efficiently than controls. Plasma cocaine concentrations were significantly higher in the early-treated group than the later-treated group despite receiving the same weight-adjusted doses. It was concluded that neonatal cocaine, when administered during a stage of brain development analogous to human third trimester, induces few behavioral effects based on the assessments used in this study. Copyright (C) 2000 Elsevier Science Inc.

AB - Prenatal cocaine treatment produces equivocal effects on spatial learning and memory; however, no data are available on neonatal treatment as a model of human third-trimester exposure. Sprague-Dawley rats were treated on postnatal days (P) 1-10 or 11-20 with cocaine (15 mg/kg x 4 per day at 2-h intervals) or saline (P1-P20) and evaluated as adults in the Morris water maze and on tests of activity, startle, scent marking, swimming immobility, and sequential learning. Neonatal cocaine had no effect on mortality; however, early treatment reduced body weight, whereas later treatment did not. Neonatal cocaine had no effects on exploratory activity, swimming ability, sequential learning, multiday activity rhythms, scent marking, or swimming immobility, but augmented acoustic startle amplitude in the early-treated group. Neonatal cocaine also produced an interaction on spatial learning in which the cocaine early-treated males performed slightly more efficiently than controls. Plasma cocaine concentrations were significantly higher in the early-treated group than the later-treated group despite receiving the same weight-adjusted doses. It was concluded that neonatal cocaine, when administered during a stage of brain development analogous to human third trimester, induces few behavioral effects based on the assessments used in this study. Copyright (C) 2000 Elsevier Science Inc.

UR - http://www.scopus.com/inward/record.url?scp=0034603498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034603498&partnerID=8YFLogxK

U2 - 10.1016/S0892-0362(99)00071-9

DO - 10.1016/S0892-0362(99)00071-9

M3 - Article

C2 - 10758355

AN - SCOPUS:0034603498

VL - 22

SP - 255

EP - 265

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 2

ER -