Evaluation of renal function in transplant patients on tacrolimus therapy

Sangeeta Agarwala, Emma Culligan, Ashok Jain, Jerry McCauley, Ron Shapiro, Pradip Chakrabarti, Gilbert Burckart, Raman Venkataramanan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Glomerular filtration rate (GFR), as measured by 24-hour creatinine clearance and clearance of iothalamate, and effective renal plasma flow (ERPF), as measured by the clearance of para-aminohippuric acid (PAH), were evaluated at 2 weeks, 1 month, and 3 months after transplantation in 8 renal transplant patients and at 1 month and 1 year after transplantation in 9 liver transplant patients receiving tacrolimus (Prograf®) therapy. In renal transplant patients, there was a significant increase in GFR after transplantation. There was no change in GFR at 1 and 3 months as compared to 2 weeks after transplantation, while ERPF (ml/min/1.73 m2) was lower (p < 0.05) at 3 months (212 ± 42) compared to 1 month (306 ± 118) after transplantation. In liver transplant patients, GFR and ERPF were below normal despite normal serum creatinine concentrations, but there was no difference in GFR or ERPF at 1 month and 1 year after transplantation. Although below normal, renal function was well preserved in transplant patients while receiving chronic tacrolimus therapy over the study period. Dosage alterations of renally eliminated drugs may be required for drugs with a narrow therapeutic index.

Original languageEnglish (US)
Pages (from-to)798-805
Number of pages8
JournalJournal of Clinical Pharmacology
Volume42
Issue number7
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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