TY - JOUR
T1 - Evaluation of skeletal muscle capillary basement membrane thickness in congestive heart failure
AU - Longhurst, J.
AU - Capone, R. J.
AU - Zelis, R.
N1 - Funding Information:
Supported in part by American Heart Association Grant No. 71–888 and Program Project Grant No. HL 14780 of the National Institutes of Health.
Funding Information:
At the time of these studies Dr. Capone was supported by National Heart and Lung Institute Research Fellowship No. HL 52380 and Dr. Longhurst was supported by a National Institutes of Health Physiology Traineeship No. USPHS 01934
PY - 1975
Y1 - 1975
N2 - Although it has been demonstrated that during isotonic grip exercise, patients with chronic congestive heart failure have an abnormally reduced forearm oxygen consumption resulting from a depressed forearm blood flow, there may be additional etiologies of this abnormality. To explore this possibility, biopsies of the pronator teres muscle were taken in eight control subjects with normal cardiac hemodynamics and in seven severely decompensated chronic congestive heart failure subjects. Each sample was fixed, stained, and photomicrographs of the sections were obtained and the capillary basement membrane thickness determined. The control capillary basement membrane thickness was 3028±187 Å (mean ± SEM) compared to the congestive heart failure thickness of 4924±538 Å (p<.01). It is possible that the increased basement membrane thickness in congestive heart failure may result from or actually cause the depressed oxygen consumption by altering diffusion.
AB - Although it has been demonstrated that during isotonic grip exercise, patients with chronic congestive heart failure have an abnormally reduced forearm oxygen consumption resulting from a depressed forearm blood flow, there may be additional etiologies of this abnormality. To explore this possibility, biopsies of the pronator teres muscle were taken in eight control subjects with normal cardiac hemodynamics and in seven severely decompensated chronic congestive heart failure subjects. Each sample was fixed, stained, and photomicrographs of the sections were obtained and the capillary basement membrane thickness determined. The control capillary basement membrane thickness was 3028±187 Å (mean ± SEM) compared to the congestive heart failure thickness of 4924±538 Å (p<.01). It is possible that the increased basement membrane thickness in congestive heart failure may result from or actually cause the depressed oxygen consumption by altering diffusion.
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U2 - 10.1378/chest.67.2.195
DO - 10.1378/chest.67.2.195
M3 - Article
C2 - 1116395
AN - SCOPUS:0016423907
VL - 67
SP - 195
EP - 198
JO - Diseases of the chest
JF - Diseases of the chest
SN - 0012-3692
IS - 2
ER -