Abstract
Although it has been demonstrated that during isotonic grip exercise, patients with chronic congestive heart failure have an abnormally reduced forearm oxygen consumption resulting from a depressed forearm blood flow, there may be additional etiologies of this abnormality. To explore this possibility, biopsies of the pronator teres muscle were taken in eight control subjects with normal cardiac hemodynamics and in seven severely decompensated chronic congestive heart failure subjects. Each sample was fixed, stained, and photomicrographs of the sections were obtained and the capillary basement membrane thickness determined. The control capillary basement membrane thickness was 3028±187 Å (mean ± SEM) compared to the congestive heart failure thickness of 4924±538 Å (p<.01). It is possible that the increased basement membrane thickness in congestive heart failure may result from or actually cause the depressed oxygen consumption by altering diffusion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 195-198 |
| Number of pages | 4 |
| Journal | CHEST |
| Volume | 67 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1975 |
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All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
- Cardiology and Cardiovascular Medicine
Cite this
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Evaluation of skeletal muscle capillary basement membrane thickness in congestive heart failure. / Longhurst, J.; Capone, R. J.; Zelis, R.
In: CHEST, Vol. 67, No. 2, 01.01.1975, p. 195-198.Research output: Contribution to journal › Article
TY - JOUR
T1 - Evaluation of skeletal muscle capillary basement membrane thickness in congestive heart failure
AU - Longhurst, J.
AU - Capone, R. J.
AU - Zelis, R.
PY - 1975/1/1
Y1 - 1975/1/1
N2 - Although it has been demonstrated that during isotonic grip exercise, patients with chronic congestive heart failure have an abnormally reduced forearm oxygen consumption resulting from a depressed forearm blood flow, there may be additional etiologies of this abnormality. To explore this possibility, biopsies of the pronator teres muscle were taken in eight control subjects with normal cardiac hemodynamics and in seven severely decompensated chronic congestive heart failure subjects. Each sample was fixed, stained, and photomicrographs of the sections were obtained and the capillary basement membrane thickness determined. The control capillary basement membrane thickness was 3028±187 Å (mean ± SEM) compared to the congestive heart failure thickness of 4924±538 Å (p<.01). It is possible that the increased basement membrane thickness in congestive heart failure may result from or actually cause the depressed oxygen consumption by altering diffusion.
AB - Although it has been demonstrated that during isotonic grip exercise, patients with chronic congestive heart failure have an abnormally reduced forearm oxygen consumption resulting from a depressed forearm blood flow, there may be additional etiologies of this abnormality. To explore this possibility, biopsies of the pronator teres muscle were taken in eight control subjects with normal cardiac hemodynamics and in seven severely decompensated chronic congestive heart failure subjects. Each sample was fixed, stained, and photomicrographs of the sections were obtained and the capillary basement membrane thickness determined. The control capillary basement membrane thickness was 3028±187 Å (mean ± SEM) compared to the congestive heart failure thickness of 4924±538 Å (p<.01). It is possible that the increased basement membrane thickness in congestive heart failure may result from or actually cause the depressed oxygen consumption by altering diffusion.
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U2 - 10.1378/chest.67.2.195
DO - 10.1378/chest.67.2.195
M3 - Article
C2 - 1116395
AN - SCOPUS:0016423907
VL - 67
SP - 195
EP - 198
JO - Chest
JF - Chest
SN - 0012-3692
IS - 2
ER -