Evidence for a third, Ir-associated histocompatibility region in the H-2 complex of the mouse

Jan Klein, Miroslav Hauptfeld, Věra Hauptfeld

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Abstract

Skin grafts transplanted from B10.HTT donors onto (A.TL × B10)F1 recipients are rapidly rejected despite the fact that the B10.HTT and A.TL strains should be carrying the same H-2 chromosomes and that both the donor and the recipient contain the B10 genome. The rejection is accompanied by a production of cytotoxic antibodies against antigens controlled by the Ir region of the H-2 complex. These unexpected findings are interpreted as evidence for a third histocompatibility locus in the H-2 complex, H-2I, located in the Ir region close to H-2K. The B10.HTT and A.TL strains are postulated to differ at this hypothetical locus, and the difference between the two strains is explained as resulting from a crossing over between the H-2t1 and H-2s chromosomes in the early history of the B10.HTT strain. The H-2 genotypes of the B10.HTT and A.TL strains are assumed to be H-2KsIrs/kSskH-2Dd and H-2KsIrkSskH-2Dd, respectively. Thus, the H-2 chromosomes of the two strains differ only in a portion of the Ir region, including the H-2I locus. The B10.HTT(H-2tt) and B10.S(7R)(H-2th) strains differ in a relatively minor histocompatibility locus, possibly residing in the Tla region outside of the H-2 complex.

Original languageEnglish (US)
Pages (from-to)45-56
Number of pages12
JournalImmunogenetics
Volume1
Issue number1
DOIs
StatePublished - Dec 1 1974

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Histocompatibility
Chromosomes, Human, Pair 2
Minor Histocompatibility Loci
Antibody Formation
Chromosomes
History
Genotype
Genome
Transplants
Antigens
Skin

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

Cite this

Klein, Jan ; Hauptfeld, Miroslav ; Hauptfeld, Věra. / Evidence for a third, Ir-associated histocompatibility region in the H-2 complex of the mouse. In: Immunogenetics. 1974 ; Vol. 1, No. 1. pp. 45-56.
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Evidence for a third, Ir-associated histocompatibility region in the H-2 complex of the mouse. / Klein, Jan; Hauptfeld, Miroslav; Hauptfeld, Věra.

In: Immunogenetics, Vol. 1, No. 1, 01.12.1974, p. 45-56.

Research output: Contribution to journalArticle

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AB - Skin grafts transplanted from B10.HTT donors onto (A.TL × B10)F1 recipients are rapidly rejected despite the fact that the B10.HTT and A.TL strains should be carrying the same H-2 chromosomes and that both the donor and the recipient contain the B10 genome. The rejection is accompanied by a production of cytotoxic antibodies against antigens controlled by the Ir region of the H-2 complex. These unexpected findings are interpreted as evidence for a third histocompatibility locus in the H-2 complex, H-2I, located in the Ir region close to H-2K. The B10.HTT and A.TL strains are postulated to differ at this hypothetical locus, and the difference between the two strains is explained as resulting from a crossing over between the H-2t1 and H-2s chromosomes in the early history of the B10.HTT strain. The H-2 genotypes of the B10.HTT and A.TL strains are assumed to be H-2KsIrs/kSskH-2Dd and H-2KsIrkSskH-2Dd, respectively. Thus, the H-2 chromosomes of the two strains differ only in a portion of the Ir region, including the H-2I locus. The B10.HTT(H-2tt) and B10.S(7R)(H-2th) strains differ in a relatively minor histocompatibility locus, possibly residing in the Tla region outside of the H-2 complex.

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