Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer

Tian Yu, John Bachman, Zhi Chun Lai

Research output: Contribution to journalComment/debatepeer-review

24 Scopus citations

Abstract

The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

Original languageEnglish (US)
Pages (from-to)1193-1196
Number of pages4
JournalGenetics
Volume195
Issue number3
DOIs
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Genetics

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