Evidence for pancreatic β-cell dysfunction in brothers of women with polycystic ovary syndrome

Susan Sam, Yeon Ah Sung, Richard Legro, Andrea Dunaif

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Hyperandrogenemia and insulin resistance are heritable traits in sisters of women with polycystic ovary syndrome (PCOS). Hyperandrogenemia also appears to be the male reproductive phenotype; however, it is less clear whether male relatives are at risk for the metabolic disorders associated with PCOS. In this study, we tested the hypothesis that brothers of women with PCOS have defects in insulin action and/or secretion. Twenty-three non-Hispanic white brothers of women with PCOS and 23 non-Hispanic white control men of comparable age matched for body mass index underwent a modified frequently sampled intravenous glucose tolerance test. Parameters of insulin sensitivity and secretion were determined using minimal-model Bergman protocol. Disposition index was significantly decreased (2540 [1080, 3172] vs 2901 [2096, 4487], P = .009) independent of a family history of diabetes mellitus, and glucose effectiveness was significantly increased (2.4 [1.9, 2.7] vs 2.0 [1.8, 2.2], P = .02) in brothers compared with control men. We conclude that brothers of women with PCOS have evidence for pancreatic β-cell dysfunction and may be at increased risk for type 2 diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalMetabolism: Clinical and Experimental
Volume57
Issue number1
DOIs
StatePublished - Jan 1 2008

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Polycystic Ovary Syndrome
Siblings
Insulin Resistance
Glucose Tolerance Test
Type 2 Diabetes Mellitus
Diabetes Mellitus
Body Mass Index
Insulin
Phenotype
Glucose

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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Evidence for pancreatic β-cell dysfunction in brothers of women with polycystic ovary syndrome. / Sam, Susan; Sung, Yeon Ah; Legro, Richard; Dunaif, Andrea.

In: Metabolism: Clinical and Experimental, Vol. 57, No. 1, 01.01.2008, p. 84-89.

Research output: Contribution to journalArticle

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