Evidence for placing the Neu-1 locus within the mouse H-2 complex

F. Figueroa, D. Klein, S. Tewarson, J. Klein

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43 Scopus citations

Abstract

Congenic lines B10.KPA42, B10.KPA132, B10.SNA57, B10.DRB62, and B10.WOA105 carry H-2 haplotypes of wild mice on the genetic background of the strain C57BL/10Sn. Two of the lines (B10.DRB62 and B10.WOA105) have H-2 haplotypes indistinguishable from H-2(v) of B.10SM. The H-2 haplotype of one line (B10.SNA57) seems to have arisen from H-2(v) by recombination between the D and Qa-2 loci. The H-2 haplotypes of the remaining two lines probably arose from H-2(v) by recombination between the C4 and D loci. Since all six and no other lines carry the rare Neu-1(a) allele, the neuraminidase-1 locus is probably located proximal to the H-2D locus. Typing of H-2(s) recombinants for the enzyme acid phosphatase liver, the processing of which is controlled by the Neu-1 locus, suggests that the locus resides between the E(α) and D loci, that is in the S region.

Original languageEnglish (US)
Pages (from-to)2089-2093
Number of pages5
JournalJournal of Immunology
Volume129
Issue number5
StatePublished - 1982

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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