TY - JOUR
T1 - Evidence for placing the Neu-1 locus within the mouse H-2 complex
AU - Figueroa, F.
AU - Klein, D.
AU - Tewarson, S.
AU - Klein, J.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1982
Y1 - 1982
N2 - Congenic lines B10.KPA42, B10.KPA132, B10.SNA57, B10.DRB62, and B10.WOA105 carry H-2 haplotypes of wild mice on the genetic background of the strain C57BL/10Sn. Two of the lines (B10.DRB62 and B10.WOA105) have H-2 haplotypes indistinguishable from H-2(v) of B.10SM. The H-2 haplotype of one line (B10.SNA57) seems to have arisen from H-2(v) by recombination between the D and Qa-2 loci. The H-2 haplotypes of the remaining two lines probably arose from H-2(v) by recombination between the C4 and D loci. Since all six and no other lines carry the rare Neu-1(a) allele, the neuraminidase-1 locus is probably located proximal to the H-2D locus. Typing of H-2(s) recombinants for the enzyme acid phosphatase liver, the processing of which is controlled by the Neu-1 locus, suggests that the locus resides between the E(α) and D loci, that is in the S region.
AB - Congenic lines B10.KPA42, B10.KPA132, B10.SNA57, B10.DRB62, and B10.WOA105 carry H-2 haplotypes of wild mice on the genetic background of the strain C57BL/10Sn. Two of the lines (B10.DRB62 and B10.WOA105) have H-2 haplotypes indistinguishable from H-2(v) of B.10SM. The H-2 haplotype of one line (B10.SNA57) seems to have arisen from H-2(v) by recombination between the D and Qa-2 loci. The H-2 haplotypes of the remaining two lines probably arose from H-2(v) by recombination between the C4 and D loci. Since all six and no other lines carry the rare Neu-1(a) allele, the neuraminidase-1 locus is probably located proximal to the H-2D locus. Typing of H-2(s) recombinants for the enzyme acid phosphatase liver, the processing of which is controlled by the Neu-1 locus, suggests that the locus resides between the E(α) and D loci, that is in the S region.
UR - http://www.scopus.com/inward/record.url?scp=0019927035&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019927035&partnerID=8YFLogxK
M3 - Article
C2 - 7119440
AN - SCOPUS:0019927035
VL - 129
SP - 2089
EP - 2093
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 5
ER -