Evidence for postmeiotic effect of t factors causing segregation distortion in mouse

Craig Hammerberg, Jan Klein

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

THE t complex of the mouse consists of a large series of genetic factors often characterised by embryonic lethality of the homozygotes, reduced male fertility of viable homozygotes, suppression of recombination over a relatively long chromosomal segment and relatively frequent occurrence in natural mouse populations. Most t factors also possess a component which interacts with the Brachyury (T) gene and causes complete absence of the tail in T/t heterozygotes. One of the most fascinating but least explored characteristics of the t factors is their effect on genetic segregation. A male mouse carrying a t factor in a heterozygous condition (t/-) often transmits the factor to almost 100% of its progeny, in defiance of the Mendelian principle requiring 1:1 segregation.

Original languageEnglish (US)
Pages (from-to)137-138
Number of pages2
JournalNature
Volume253
Issue number5487
DOIs
StatePublished - Dec 1 1975

All Science Journal Classification (ASJC) codes

  • General

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