Evidence of a myogenic response in vasomotor control of forearm and palm cutaneous microcirculations

S. Durand, R. Zhang, Jian Cui, T. E. Wilson, C. G. Crandall

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Previous investigations of autoregulatory mechanisms in the control of skin blood flow suffer from the possibility of interfering effects of the autonomic nervous system. To address this question, in 11 subjects cutaneous vascular responses were measured during acute changes in perfusion pressure (using Valsalva maneuver; VM) before and after ganglionic blockade via systemic trimethaphan infusion. Cutaneous vascular conductance at baseline (CVC base) and during the last 5 s of the VM (CVCVM) were measured from forearm (nonglabrous) and palm (glabrous) skin. During the VM without ganglionic blockade, compared with CVCbase, CVCVM decreased significantly at the palm [0.79 ± 0.17 to 0.55 ± 0.17 arbitrary units (AU)/mmHg; P = 0.002] but was unchanged at the forearm (0.13 ± 0.02 to 0.16 ± 0.02 AU/mmHg; P = 0.50). After ganglionic blockade, VM induced pronounced decreases in perfusion pressure, which resulted in significant increases in CVCVM at both forearm (0.19 ± 0.03 to 0.31 ± 0.07 AU/mmHg; P = 0.008) and palm (1.84 ± 0.29 to 2.76 ± 0.63 AU/mmHg; P = 0.003) sites. These results suggest that, devoid of autonomic control, both glabrous and nonglabrous skin are capable of exhibiting vasomotor autoregulation during pronounced reductions in perfusion pressure.

Original languageEnglish (US)
Pages (from-to)535-539
Number of pages5
JournalJournal of Applied Physiology
Volume97
Issue number2
DOIs
StatePublished - Aug 1 2004

Fingerprint

Microcirculation
Forearm
Skin
Perfusion
Pressure
Blood Vessels
Trimethaphan
Valsalva Maneuver
Autonomic Nervous System
Homeostasis

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Durand, S. ; Zhang, R. ; Cui, Jian ; Wilson, T. E. ; Crandall, C. G. / Evidence of a myogenic response in vasomotor control of forearm and palm cutaneous microcirculations. In: Journal of Applied Physiology. 2004 ; Vol. 97, No. 2. pp. 535-539.
@article{e3fce86a61fa40d791507f3e3c447f61,
title = "Evidence of a myogenic response in vasomotor control of forearm and palm cutaneous microcirculations",
abstract = "Previous investigations of autoregulatory mechanisms in the control of skin blood flow suffer from the possibility of interfering effects of the autonomic nervous system. To address this question, in 11 subjects cutaneous vascular responses were measured during acute changes in perfusion pressure (using Valsalva maneuver; VM) before and after ganglionic blockade via systemic trimethaphan infusion. Cutaneous vascular conductance at baseline (CVC base) and during the last 5 s of the VM (CVCVM) were measured from forearm (nonglabrous) and palm (glabrous) skin. During the VM without ganglionic blockade, compared with CVCbase, CVCVM decreased significantly at the palm [0.79 ± 0.17 to 0.55 ± 0.17 arbitrary units (AU)/mmHg; P = 0.002] but was unchanged at the forearm (0.13 ± 0.02 to 0.16 ± 0.02 AU/mmHg; P = 0.50). After ganglionic blockade, VM induced pronounced decreases in perfusion pressure, which resulted in significant increases in CVCVM at both forearm (0.19 ± 0.03 to 0.31 ± 0.07 AU/mmHg; P = 0.008) and palm (1.84 ± 0.29 to 2.76 ± 0.63 AU/mmHg; P = 0.003) sites. These results suggest that, devoid of autonomic control, both glabrous and nonglabrous skin are capable of exhibiting vasomotor autoregulation during pronounced reductions in perfusion pressure.",
author = "S. Durand and R. Zhang and Jian Cui and Wilson, {T. E.} and Crandall, {C. G.}",
year = "2004",
month = "8",
day = "1",
doi = "10.1152/japplphysiol.01299.2003",
language = "English (US)",
volume = "97",
pages = "535--539",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "2",

}

Evidence of a myogenic response in vasomotor control of forearm and palm cutaneous microcirculations. / Durand, S.; Zhang, R.; Cui, Jian; Wilson, T. E.; Crandall, C. G.

In: Journal of Applied Physiology, Vol. 97, No. 2, 01.08.2004, p. 535-539.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evidence of a myogenic response in vasomotor control of forearm and palm cutaneous microcirculations

AU - Durand, S.

AU - Zhang, R.

AU - Cui, Jian

AU - Wilson, T. E.

AU - Crandall, C. G.

PY - 2004/8/1

Y1 - 2004/8/1

N2 - Previous investigations of autoregulatory mechanisms in the control of skin blood flow suffer from the possibility of interfering effects of the autonomic nervous system. To address this question, in 11 subjects cutaneous vascular responses were measured during acute changes in perfusion pressure (using Valsalva maneuver; VM) before and after ganglionic blockade via systemic trimethaphan infusion. Cutaneous vascular conductance at baseline (CVC base) and during the last 5 s of the VM (CVCVM) were measured from forearm (nonglabrous) and palm (glabrous) skin. During the VM without ganglionic blockade, compared with CVCbase, CVCVM decreased significantly at the palm [0.79 ± 0.17 to 0.55 ± 0.17 arbitrary units (AU)/mmHg; P = 0.002] but was unchanged at the forearm (0.13 ± 0.02 to 0.16 ± 0.02 AU/mmHg; P = 0.50). After ganglionic blockade, VM induced pronounced decreases in perfusion pressure, which resulted in significant increases in CVCVM at both forearm (0.19 ± 0.03 to 0.31 ± 0.07 AU/mmHg; P = 0.008) and palm (1.84 ± 0.29 to 2.76 ± 0.63 AU/mmHg; P = 0.003) sites. These results suggest that, devoid of autonomic control, both glabrous and nonglabrous skin are capable of exhibiting vasomotor autoregulation during pronounced reductions in perfusion pressure.

AB - Previous investigations of autoregulatory mechanisms in the control of skin blood flow suffer from the possibility of interfering effects of the autonomic nervous system. To address this question, in 11 subjects cutaneous vascular responses were measured during acute changes in perfusion pressure (using Valsalva maneuver; VM) before and after ganglionic blockade via systemic trimethaphan infusion. Cutaneous vascular conductance at baseline (CVC base) and during the last 5 s of the VM (CVCVM) were measured from forearm (nonglabrous) and palm (glabrous) skin. During the VM without ganglionic blockade, compared with CVCbase, CVCVM decreased significantly at the palm [0.79 ± 0.17 to 0.55 ± 0.17 arbitrary units (AU)/mmHg; P = 0.002] but was unchanged at the forearm (0.13 ± 0.02 to 0.16 ± 0.02 AU/mmHg; P = 0.50). After ganglionic blockade, VM induced pronounced decreases in perfusion pressure, which resulted in significant increases in CVCVM at both forearm (0.19 ± 0.03 to 0.31 ± 0.07 AU/mmHg; P = 0.008) and palm (1.84 ± 0.29 to 2.76 ± 0.63 AU/mmHg; P = 0.003) sites. These results suggest that, devoid of autonomic control, both glabrous and nonglabrous skin are capable of exhibiting vasomotor autoregulation during pronounced reductions in perfusion pressure.

UR - http://www.scopus.com/inward/record.url?scp=3242693237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242693237&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.01299.2003

DO - 10.1152/japplphysiol.01299.2003

M3 - Article

C2 - 15090486

AN - SCOPUS:3242693237

VL - 97

SP - 535

EP - 539

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -