Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women

Robert A. Wild, Mary Bartholomew, Deborah Applebaum-Bowden, Laurence Demers, William Hazzard, Richard J. Santen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Fifty-one hyperandrogenic women had their lipoprotein lipid profiles determined. Free and albumin-bound testosterone was associated with triglycerides and with high-density lipoprotein cholesterol independent of fasting insulin levels, percent ideal body weight, and waist/hip ratio. To gain insight into mechanisms of these lipid alterations, the women were subgrouped according to apparent source of androgen excess. Whereas all groups had low levels of high-density lipoprotein-2 cholesterol and high triglyceride concentrations, only in those with high luteinizing hormone-to-follicle-stimulating hormone ratios was free and albumin-bound testosterone associated with triglycerides and high-density lipoprotein cholesterol independent of fasting insulin levels. Relationships between percent ideal body weight and waist/hip ratios, free and albumin-bound testosterone, sex hormone binding globulin, fasting insulin and 2-hour insulin levels and blood pressure are not significant in all subgroups, suggesting differing endocrinological influences and differing mechanisms for lipoprotein lipid alterations.

Original languageEnglish (US)
Pages (from-to)1998-2005
Number of pages8
JournalAmerican Journal of Obstetrics and Gynecology
Volume163
Issue number6 PART 1
DOIs
StatePublished - Jan 1 1990

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Lipoproteins
Insulin
HDL Cholesterol
Lipids
Testosterone
Ideal Body Weight
Albumins
Fasting
Triglycerides
Waist-Hip Ratio
HDL2 Lipoprotein
Sex Hormone-Binding Globulin
Follicle Stimulating Hormone
Luteinizing Hormone
Androgens
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Wild, R. A., Bartholomew, M., Applebaum-Bowden, D., Demers, L., Hazzard, W., & Santen, R. J. (1990). Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women. American Journal of Obstetrics and Gynecology, 163(6 PART 1), 1998-2005. https://doi.org/10.1016/0002-9378(90)90787-8
Wild, Robert A. ; Bartholomew, Mary ; Applebaum-Bowden, Deborah ; Demers, Laurence ; Hazzard, William ; Santen, Richard J. / Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women. In: American Journal of Obstetrics and Gynecology. 1990 ; Vol. 163, No. 6 PART 1. pp. 1998-2005.
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Wild, RA, Bartholomew, M, Applebaum-Bowden, D, Demers, L, Hazzard, W & Santen, RJ 1990, 'Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women', American Journal of Obstetrics and Gynecology, vol. 163, no. 6 PART 1, pp. 1998-2005. https://doi.org/10.1016/0002-9378(90)90787-8

Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women. / Wild, Robert A.; Bartholomew, Mary; Applebaum-Bowden, Deborah; Demers, Laurence; Hazzard, William; Santen, Richard J.

In: American Journal of Obstetrics and Gynecology, Vol. 163, No. 6 PART 1, 01.01.1990, p. 1998-2005.

Research output: Contribution to journalArticle

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