TY - JOUR
T1 - Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women
AU - Wild, Robert A.
AU - Bartholomew, Mary
AU - Applebaum-Bowden, Deborah
AU - Demers, Laurence M.
AU - Hazzard, William
AU - Santen, Richard J.
N1 - Funding Information:
From the Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center: Center for Biostatistics, Hershey Medical Center,h Department of Medicine, Bowman Gray School of Medicine,' Department of Medicine, Hershey Medical Center/ and Department of Pathology, Hershey Medical Center.' Presented at the Thirty-seventh Annual Meeting of the Society for Gynecologic Investigation, St. Louil, Missouri, March 21-24,1990. Supported in whole or in part by grants from Pennsylvania American Heart Association, Grant No. S07-RR 05680-19 awarded by the Biomedical Research Support Grant Program, Division of Research Resources, National Institutes of Heatlh, and the Presbyterian Health Foundation of Oklahoma City, Oklahoma. Reprint requests: Robert A. Wild, MD, Oklahoma University Health Sciences Center, Department of Obstetrics and Gynecology, 920 S.L. Young Blvd., Oklahoma City, OK 73104.
PY - 1990/12
Y1 - 1990/12
N2 - Fifty-one hyperandrogenic women had their lipoprotein lipid profiles determined. Free and albumin-bound testosterone was associated with triglycerides and with high-density lipoprotein cholesterol independent of fasting insulin levels, percent ideal body weight, and waist/hip ratio. To gain insight into mechanisms of these lipid alterations, the women were subgrouped according to apparent source of androgen excess. Whereas all groups had low levels of high-density lipoprotein-2 cholesterol and high triglyceride concentrations, only in those with high luteinizing hormone-to-follicle-stimulating hormone ratios was free and albumin-bound testosterone associated with triglycerides and high-density lipoprotein cholesterol independent of fasting insulin levels. Relationships between percent ideal body weight and waist/hip ratios, free and albumin-bound testosterone, sex hormone binding globulin, fasting insulin and 2-hour insulin levels and blood pressure are not significant in all subgroups, suggesting differing endocrinological influences and differing mechanisms for lipoprotein lipid alterations.
AB - Fifty-one hyperandrogenic women had their lipoprotein lipid profiles determined. Free and albumin-bound testosterone was associated with triglycerides and with high-density lipoprotein cholesterol independent of fasting insulin levels, percent ideal body weight, and waist/hip ratio. To gain insight into mechanisms of these lipid alterations, the women were subgrouped according to apparent source of androgen excess. Whereas all groups had low levels of high-density lipoprotein-2 cholesterol and high triglyceride concentrations, only in those with high luteinizing hormone-to-follicle-stimulating hormone ratios was free and albumin-bound testosterone associated with triglycerides and high-density lipoprotein cholesterol independent of fasting insulin levels. Relationships between percent ideal body weight and waist/hip ratios, free and albumin-bound testosterone, sex hormone binding globulin, fasting insulin and 2-hour insulin levels and blood pressure are not significant in all subgroups, suggesting differing endocrinological influences and differing mechanisms for lipoprotein lipid alterations.
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U2 - 10.1016/0002-9378(90)90787-8
DO - 10.1016/0002-9378(90)90787-8
M3 - Article
C2 - 2256513
AN - SCOPUS:0025615238
VL - 163
SP - 1998
EP - 2005
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 6 PART 1
ER -