Abstract
Fifty-one hyperandrogenic women had their lipoprotein lipid profiles determined. Free and albumin-bound testosterone was associated with triglycerides and with high-density lipoprotein cholesterol independent of fasting insulin levels, percent ideal body weight, and waist/hip ratio. To gain insight into mechanisms of these lipid alterations, the women were subgrouped according to apparent source of androgen excess. Whereas all groups had low levels of high-density lipoprotein-2 cholesterol and high triglyceride concentrations, only in those with high luteinizing hormone-to-follicle-stimulating hormone ratios was free and albumin-bound testosterone associated with triglycerides and high-density lipoprotein cholesterol independent of fasting insulin levels. Relationships between percent ideal body weight and waist/hip ratios, free and albumin-bound testosterone, sex hormone binding globulin, fasting insulin and 2-hour insulin levels and blood pressure are not significant in all subgroups, suggesting differing endocrinological influences and differing mechanisms for lipoprotein lipid alterations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1998-2005 |
| Number of pages | 8 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 163 |
| Issue number | 6 PART 1 |
| DOIs | |
| State | Published - Jan 1 1990 |
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All Science Journal Classification (ASJC) codes
- Obstetrics and Gynecology
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Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women. / Wild, Robert A.; Bartholomew, Mary; Applebaum-Bowden, Deborah; Demers, Laurence; Hazzard, William; Santen, Richard J.
In: American Journal of Obstetrics and Gynecology, Vol. 163, No. 6 PART 1, 01.01.1990, p. 1998-2005.Research output: Contribution to journal › Article
TY - JOUR
T1 - Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women
AU - Wild, Robert A.
AU - Bartholomew, Mary
AU - Applebaum-Bowden, Deborah
AU - Demers, Laurence
AU - Hazzard, William
AU - Santen, Richard J.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Fifty-one hyperandrogenic women had their lipoprotein lipid profiles determined. Free and albumin-bound testosterone was associated with triglycerides and with high-density lipoprotein cholesterol independent of fasting insulin levels, percent ideal body weight, and waist/hip ratio. To gain insight into mechanisms of these lipid alterations, the women were subgrouped according to apparent source of androgen excess. Whereas all groups had low levels of high-density lipoprotein-2 cholesterol and high triglyceride concentrations, only in those with high luteinizing hormone-to-follicle-stimulating hormone ratios was free and albumin-bound testosterone associated with triglycerides and high-density lipoprotein cholesterol independent of fasting insulin levels. Relationships between percent ideal body weight and waist/hip ratios, free and albumin-bound testosterone, sex hormone binding globulin, fasting insulin and 2-hour insulin levels and blood pressure are not significant in all subgroups, suggesting differing endocrinological influences and differing mechanisms for lipoprotein lipid alterations.
AB - Fifty-one hyperandrogenic women had their lipoprotein lipid profiles determined. Free and albumin-bound testosterone was associated with triglycerides and with high-density lipoprotein cholesterol independent of fasting insulin levels, percent ideal body weight, and waist/hip ratio. To gain insight into mechanisms of these lipid alterations, the women were subgrouped according to apparent source of androgen excess. Whereas all groups had low levels of high-density lipoprotein-2 cholesterol and high triglyceride concentrations, only in those with high luteinizing hormone-to-follicle-stimulating hormone ratios was free and albumin-bound testosterone associated with triglycerides and high-density lipoprotein cholesterol independent of fasting insulin levels. Relationships between percent ideal body weight and waist/hip ratios, free and albumin-bound testosterone, sex hormone binding globulin, fasting insulin and 2-hour insulin levels and blood pressure are not significant in all subgroups, suggesting differing endocrinological influences and differing mechanisms for lipoprotein lipid alterations.
UR - http://www.scopus.com/inward/record.url?scp=0025615238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025615238&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(90)90787-8
DO - 10.1016/0002-9378(90)90787-8
M3 - Article
C2 - 2256513
AN - SCOPUS:0025615238
VL - 163
SP - 1998
EP - 2005
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 6 PART 1
ER -