Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women

Robert A. Wild, Mary Bartholomew, Deborah Applebaum-Bowden, Laurence M. Demers, William Hazzard, Richard J. Santen

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Abstract

Fifty-one hyperandrogenic women had their lipoprotein lipid profiles determined. Free and albumin-bound testosterone was associated with triglycerides and with high-density lipoprotein cholesterol independent of fasting insulin levels, percent ideal body weight, and waist/hip ratio. To gain insight into mechanisms of these lipid alterations, the women were subgrouped according to apparent source of androgen excess. Whereas all groups had low levels of high-density lipoprotein-2 cholesterol and high triglyceride concentrations, only in those with high luteinizing hormone-to-follicle-stimulating hormone ratios was free and albumin-bound testosterone associated with triglycerides and high-density lipoprotein cholesterol independent of fasting insulin levels. Relationships between percent ideal body weight and waist/hip ratios, free and albumin-bound testosterone, sex hormone binding globulin, fasting insulin and 2-hour insulin levels and blood pressure are not significant in all subgroups, suggesting differing endocrinological influences and differing mechanisms for lipoprotein lipid alterations.

Original languageEnglish (US)
Pages (from-to)1998-2005
Number of pages8
JournalAmerican journal of obstetrics and gynecology
Volume163
Issue number6 PART 1
DOIs
StatePublished - Dec 1990

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All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Wild, R. A., Bartholomew, M., Applebaum-Bowden, D., Demers, L. M., Hazzard, W., & Santen, R. J. (1990). Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women. American journal of obstetrics and gynecology, 163(6 PART 1), 1998-2005. https://doi.org/10.1016/0002-9378(90)90787-8