Evidence of subthalamic PGO-like waves during REM sleep in humans: A deep brain polysomnographic study

Julio Fernández-Mendoza, Beatriz Lozano, Fernando Seijo, Elena Santamarta-Liébana, Maria José Ramos-Platón, Antonio Vela-Bueno, Fernando Fernández-González

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Study Objectives: The aim of this study was to examine whether the subthalamic nucleus (STN) plays a role in the transmission of PGO-like waves during REM sleep in humans. Design: Simultaneous recordings from deep brain electrodes to record local field potentials (LFPs), and standard polysomnography to ascertain sleep/wake states. Setting: Main Hospital, department of clinical neurophysiology sleep laboratory. Participants: 12 individuals with Parkinson's disease, with electrodes implanted in the STN; and, as a control for localization purposes, 4 cluster headache patients with electrodes implanted in the posterior hypothalamus. Interventions: All subjects underwent functional neurosurgery for implantation of deep brain stimulation electrodes. Results: Sharp, polarity-reversed LFPs were recorded within the STN during REM sleep in humans. These subthalamic PGO-like waves (2-3 Hz, 80-200 μV, and 300-500 msec) appeared during REM epochs as singlets or in clusters of 3-13 waves. During the pre-REM period, subthalamic PGO-like waves were temporally related to drops in the submental electromyogram and/or onset of muscular atonia. Clusters of PGO-like waves occurred typically before and during the bursts of rapid eye movements and were associated with an enhancement in fast (15-35 Hz) subthalamic oscillatory activity. Conclusion: Subthalamic PGO-like waves can be recorded during pre-REM and REM sleep in humans. Our data suggest that the STN may play an active role in an ascending activating network implicated in the transmission of PGO waves during REM sleep in humans.

Original languageEnglish (US)
Pages (from-to)1117-1126
Number of pages10
JournalSleep
Volume32
Issue number9
DOIs
StatePublished - Sep 1 2009

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REM Sleep
Subthalamic Nucleus
Brain
Implanted Electrodes
Sleep
Electrodes
Posterior Hypothalamus
Cluster Headache
Neurophysiology
Deep Brain Stimulation
Polysomnography
Hospital Departments
Neurosurgery
Electromyography
Parkinson Disease

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Physiology (medical)

Cite this

Fernández-Mendoza, J., Lozano, B., Seijo, F., Santamarta-Liébana, E., Ramos-Platón, M. J., Vela-Bueno, A., & Fernández-González, F. (2009). Evidence of subthalamic PGO-like waves during REM sleep in humans: A deep brain polysomnographic study. Sleep, 32(9), 1117-1126. https://doi.org/10.1093/sleep/32.9.1117
Fernández-Mendoza, Julio ; Lozano, Beatriz ; Seijo, Fernando ; Santamarta-Liébana, Elena ; Ramos-Platón, Maria José ; Vela-Bueno, Antonio ; Fernández-González, Fernando. / Evidence of subthalamic PGO-like waves during REM sleep in humans : A deep brain polysomnographic study. In: Sleep. 2009 ; Vol. 32, No. 9. pp. 1117-1126.
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abstract = "Study Objectives: The aim of this study was to examine whether the subthalamic nucleus (STN) plays a role in the transmission of PGO-like waves during REM sleep in humans. Design: Simultaneous recordings from deep brain electrodes to record local field potentials (LFPs), and standard polysomnography to ascertain sleep/wake states. Setting: Main Hospital, department of clinical neurophysiology sleep laboratory. Participants: 12 individuals with Parkinson's disease, with electrodes implanted in the STN; and, as a control for localization purposes, 4 cluster headache patients with electrodes implanted in the posterior hypothalamus. Interventions: All subjects underwent functional neurosurgery for implantation of deep brain stimulation electrodes. Results: Sharp, polarity-reversed LFPs were recorded within the STN during REM sleep in humans. These subthalamic PGO-like waves (2-3 Hz, 80-200 μV, and 300-500 msec) appeared during REM epochs as singlets or in clusters of 3-13 waves. During the pre-REM period, subthalamic PGO-like waves were temporally related to drops in the submental electromyogram and/or onset of muscular atonia. Clusters of PGO-like waves occurred typically before and during the bursts of rapid eye movements and were associated with an enhancement in fast (15-35 Hz) subthalamic oscillatory activity. Conclusion: Subthalamic PGO-like waves can be recorded during pre-REM and REM sleep in humans. Our data suggest that the STN may play an active role in an ascending activating network implicated in the transmission of PGO waves during REM sleep in humans.",
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Fernández-Mendoza, J, Lozano, B, Seijo, F, Santamarta-Liébana, E, Ramos-Platón, MJ, Vela-Bueno, A & Fernández-González, F 2009, 'Evidence of subthalamic PGO-like waves during REM sleep in humans: A deep brain polysomnographic study', Sleep, vol. 32, no. 9, pp. 1117-1126. https://doi.org/10.1093/sleep/32.9.1117

Evidence of subthalamic PGO-like waves during REM sleep in humans : A deep brain polysomnographic study. / Fernández-Mendoza, Julio; Lozano, Beatriz; Seijo, Fernando; Santamarta-Liébana, Elena; Ramos-Platón, Maria José; Vela-Bueno, Antonio; Fernández-González, Fernando.

In: Sleep, Vol. 32, No. 9, 01.09.2009, p. 1117-1126.

Research output: Contribution to journalArticle

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T1 - Evidence of subthalamic PGO-like waves during REM sleep in humans

T2 - A deep brain polysomnographic study

AU - Fernández-Mendoza, Julio

AU - Lozano, Beatriz

AU - Seijo, Fernando

AU - Santamarta-Liébana, Elena

AU - Ramos-Platón, Maria José

AU - Vela-Bueno, Antonio

AU - Fernández-González, Fernando

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Study Objectives: The aim of this study was to examine whether the subthalamic nucleus (STN) plays a role in the transmission of PGO-like waves during REM sleep in humans. Design: Simultaneous recordings from deep brain electrodes to record local field potentials (LFPs), and standard polysomnography to ascertain sleep/wake states. Setting: Main Hospital, department of clinical neurophysiology sleep laboratory. Participants: 12 individuals with Parkinson's disease, with electrodes implanted in the STN; and, as a control for localization purposes, 4 cluster headache patients with electrodes implanted in the posterior hypothalamus. Interventions: All subjects underwent functional neurosurgery for implantation of deep brain stimulation electrodes. Results: Sharp, polarity-reversed LFPs were recorded within the STN during REM sleep in humans. These subthalamic PGO-like waves (2-3 Hz, 80-200 μV, and 300-500 msec) appeared during REM epochs as singlets or in clusters of 3-13 waves. During the pre-REM period, subthalamic PGO-like waves were temporally related to drops in the submental electromyogram and/or onset of muscular atonia. Clusters of PGO-like waves occurred typically before and during the bursts of rapid eye movements and were associated with an enhancement in fast (15-35 Hz) subthalamic oscillatory activity. Conclusion: Subthalamic PGO-like waves can be recorded during pre-REM and REM sleep in humans. Our data suggest that the STN may play an active role in an ascending activating network implicated in the transmission of PGO waves during REM sleep in humans.

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Fernández-Mendoza J, Lozano B, Seijo F, Santamarta-Liébana E, Ramos-Platón MJ, Vela-Bueno A et al. Evidence of subthalamic PGO-like waves during REM sleep in humans: A deep brain polysomnographic study. Sleep. 2009 Sep 1;32(9):1117-1126. https://doi.org/10.1093/sleep/32.9.1117