Evolution and structural characteristics of plant voltage-gated K + channels

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15 Scopus citations

Abstract

Plant voltage-gated K + channels have been referred to as “plant Shakers” in reference to animal Shaker channels, the first K + channels identified. Recent advances in our knowledge of K + channel evolution and structure have significantly deepened the divide between these plant and animal K + channels, suggesting that it is time to completely retire the “plant Shaker” designation. Evolutionary genomics reveals that plant voltage-gated K + channels and metazoan Shakers derive from distinct prokaryotic ancestors. The plant channels belong to a lineage that includes cyclic nucleotide-gated channels and metazoan ether-à-go-go and hyperpolarization-activated, cyclic nucleotide-gated channels. We refer to this lineage as the CNBD channel superfamily, because all these channels share a cytoplasmic gating domain homologous to cyclic nucleotide binding domains. The first structures of CNBD superfamily channels reveal marked differences in coupling between the voltage sensor and ion-conducting pore relative to metazoan Shaker channels. Viewing plant voltage-gated K + channel function through the lens of CNBD superfamily structures should lead to insights into how these channels are regulated.

Original languageEnglish (US)
Pages (from-to)2898-2909
Number of pages12
JournalPlant Cell
Volume30
Issue number12
DOIs
StatePublished - Dec 2018

All Science Journal Classification (ASJC) codes

  • Plant Science
  • Cell Biology

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