Evolution of microsatellite alleles in four species of mice (genus Apodemus)

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Microsatellite length variation was investigated at a highly variable microsatellite locus in four species of Apodemus. Information obtained from microsatellite allele sequences was contrasted with allele sizes, which included 18 electromorphs. Additional analysis of a 400-bp unique sequence in the flanking region identified 26 different haplotype sequences or 'true' alleles in the sample. Three molecular mechanisms, namely, (1) addition/deletion of repeats, (2) substitutions and indels in the flanking region, and (3) mutations interrupting the repeat, contributed to the generation of allelic variation. Size homoplasy can be inferred for alleles within populations, from different populations of the same species, and from different species. We propose that microsatellite flanking sequences may be informative markers for investigating mutation processes in microsatellite repeats as well as phylogenetic relationships among alleles, populations, and species.

Original languageEnglish (US)
Pages (from-to)166-172
Number of pages7
JournalJournal Of Molecular Evolution
Volume51
Issue number2
DOIs
StatePublished - Jan 1 2000

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Murinae
Apodemus
Microsatellite Repeats
allele
Alleles
microsatellite repeats
alleles
mice
mutation
3' Flanking Region
Population
Mutation
Haplotypes
haplotypes
substitution
phylogenetics
loci
phylogeny

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

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abstract = "Microsatellite length variation was investigated at a highly variable microsatellite locus in four species of Apodemus. Information obtained from microsatellite allele sequences was contrasted with allele sizes, which included 18 electromorphs. Additional analysis of a 400-bp unique sequence in the flanking region identified 26 different haplotype sequences or 'true' alleles in the sample. Three molecular mechanisms, namely, (1) addition/deletion of repeats, (2) substitutions and indels in the flanking region, and (3) mutations interrupting the repeat, contributed to the generation of allelic variation. Size homoplasy can be inferred for alleles within populations, from different populations of the same species, and from different species. We propose that microsatellite flanking sequences may be informative markers for investigating mutation processes in microsatellite repeats as well as phylogenetic relationships among alleles, populations, and species.",
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Evolution of microsatellite alleles in four species of mice (genus Apodemus). / Makova, Kateryna Dmytrivna; Nekrutenko, Anton; Baker, Robert J.

In: Journal Of Molecular Evolution, Vol. 51, No. 2, 01.01.2000, p. 166-172.

Research output: Contribution to journalArticle

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