Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer

Ross R. Keller, Edward Gunther

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Keller and Gunther show that Wnt-driven mammary cancers challenged with simulated targeted therapy (Wnt withdrawal) undergo clonal evolution, which stringently selects for mutations that restore a “just right” level of oncogenic signaling. Therefore, cancer relapses emerge from rare subclones that are encumbered by an untapped vulnerability to oncogene overdose.

Original languageEnglish (US)
Pages (from-to)893-905.e4
JournalCell Reports
Volume26
Issue number4
DOIs
StatePublished - Jan 22 2019

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Clonal Evolution
Oncogenes
Breast Neoplasms
Recurrence
Mutation
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer. / Keller, Ross R.; Gunther, Edward.

In: Cell Reports, Vol. 26, No. 4, 22.01.2019, p. 893-905.e4.

Research output: Contribution to journalArticle

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