Abstract
Keller and Gunther show that Wnt-driven mammary cancers challenged with simulated targeted therapy (Wnt withdrawal) undergo clonal evolution, which stringently selects for mutations that restore a “just right” level of oncogenic signaling. Therefore, cancer relapses emerge from rare subclones that are encumbered by an untapped vulnerability to oncogene overdose.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 893-905.e4 |
| Journal | Cell Reports |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 22 2019 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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}
Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer. / Keller, Ross R.; Gunther, Edward J.
In: Cell Reports, Vol. 26, No. 4, 22.01.2019, p. 893-905.e4.Research output: Contribution to journal › Article
TY - JOUR
T1 - Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer
AU - Keller, Ross R.
AU - Gunther, Edward J.
PY - 2019/1/22
Y1 - 2019/1/22
N2 - Keller and Gunther show that Wnt-driven mammary cancers challenged with simulated targeted therapy (Wnt withdrawal) undergo clonal evolution, which stringently selects for mutations that restore a “just right” level of oncogenic signaling. Therefore, cancer relapses emerge from rare subclones that are encumbered by an untapped vulnerability to oncogene overdose.
AB - Keller and Gunther show that Wnt-driven mammary cancers challenged with simulated targeted therapy (Wnt withdrawal) undergo clonal evolution, which stringently selects for mutations that restore a “just right” level of oncogenic signaling. Therefore, cancer relapses emerge from rare subclones that are encumbered by an untapped vulnerability to oncogene overdose.
UR - http://www.scopus.com/inward/record.url?scp=85059735246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059735246&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2018.12.096
DO - 10.1016/j.celrep.2018.12.096
M3 - Article
C2 - 30673612
AN - SCOPUS:85059735246
VL - 26
SP - 893-905.e4
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 4
ER -