@article{b4878f82b2cb4c11bfe68cbdd1281c0b,
title = "Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer",
abstract = "Keller and Gunther show that Wnt-driven mammary cancers challenged with simulated targeted therapy (Wnt withdrawal) undergo clonal evolution, which stringently selects for mutations that restore a “just right” level of oncogenic signaling. Therefore, cancer relapses emerge from rare subclones that are encumbered by an untapped vulnerability to oncogene overdose.",
author = "Keller, {Ross R.} and Gunther, {Edward J.}",
note = "Funding Information: We thank Aswathy Sebastian and Istvan Albert of the Penn State Bioinformatics Consulting Center for expert help with processing and analyzing of Illumina sequencing outputs. High-throughput sequencing was performed through the Penn State Genomics Core Facility (University Park, PA, USA). We thank members of the Gunther laboratory for critical review of the manuscript. This work was supported by grants from the National Cancer Institute ( R01 CA152222 and R01 CA212584 ) and funding received from the benefactors of the Jake Gittlen Laboratories for Cancer Research . Animal housing was provided through a facility constructed with support from a Research Facilities Improvement Grant ( C06 RR-15428-01 ) from the National Center for Research Resources . Funding Information: We thank Aswathy Sebastian and Istvan Albert of the Penn State Bioinformatics Consulting Center for expert help with processing and analyzing of Illumina sequencing outputs. High-throughput sequencing was performed through the Penn State Genomics Core Facility (University Park, PA, USA). We thank members of the Gunther laboratory for critical review of the manuscript. This work was supported by grants from the National Cancer Institute (R01 CA152222 and R01 CA212584) and funding received from the benefactors of the Jake Gittlen Laboratories for Cancer Research. Animal housing was provided through a facility constructed with support from a Research Facilities Improvement Grant (C06 RR-15428-01) from the National Center for Research Resources. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = jan,
day = "22",
doi = "10.1016/j.celrep.2018.12.096",
language = "English (US)",
volume = "26",
pages = "893--905.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",
}