Evolutionary dynamics of tumor-stroma interactions in multiple myeloma

Javad Salimi Sartakhti, Mohammad Hossein Manshaei, Soroosh Bateni, Marco Archetti

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cancer cells and stromal cells cooperate by exchanging diffusible factors that sustain tumor growth, a form of frequency-dependent selection that can be studied in the framework of evolutionary game theory. In the case of multiple myeloma, three types of cells (malignant plasma cells, osteoblasts and osteoclasts) exchange growth factors with different effects, and tumor-stroma interactions have been analysed using a model of cooperation with pairwise interactions. Here we show that a model in which growth factors have autocrine and paracrine effects on multiple cells, a more realistic assumption for tumor-stroma interactions, leads to different results, with implications for disease progression and treatment. In particular, the model reveals that reducing the number of malignant plasma cells below a critical threshold can lead to their extinction and thus to restore a healthy balance between osteoclast and osteoblast, a result in line with current therapies against multiple myeloma.

Original languageEnglish (US)
Article numbere0168856
JournalPloS one
Volume11
Issue number12
DOIs
StatePublished - Dec 2016

Fingerprint

myeloma
Multiple Myeloma
Tumors
osteoclasts
osteoblasts
plasma cells
Osteoblasts
growth factors
neoplasms
Intercellular Signaling Peptides and Proteins
Osteoclasts
Plasma Cells
Plasmas
Neoplasms
game theory
stromal cells
Game theory
Game Theory
disease course
extinction

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Sartakhti, Javad Salimi ; Manshaei, Mohammad Hossein ; Bateni, Soroosh ; Archetti, Marco. / Evolutionary dynamics of tumor-stroma interactions in multiple myeloma. In: PloS one. 2016 ; Vol. 11, No. 12.
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Evolutionary dynamics of tumor-stroma interactions in multiple myeloma. / Sartakhti, Javad Salimi; Manshaei, Mohammad Hossein; Bateni, Soroosh; Archetti, Marco.

In: PloS one, Vol. 11, No. 12, e0168856, 12.2016.

Research output: Contribution to journalArticle

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AU - Manshaei, Mohammad Hossein

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